Mood - Lithium Flashcards
1
Q
DOC for bipolar disorders
A
lithium
2
Q
MOA: prevents recycling of inositol (decrease PIP2) by blocking inositol monophosphate
A
lithium
3
Q
narrow TI tremor flu like symptoms life threatening seizures hypothyroidism nephrogenic DI
A
lithium SE
4
Q
causes Ebstein’s anomaly - malformed tricuspid valve
A
lithium
5
Q
CI: sick sinus syndrome
A
lithium
6
Q
due to scar like damage to electrical pathway in heart
A
sick sinus syndrome
7
Q
1st signs: anorexia, vomiting, gross tremor, ataxia, confusion, sleepiness
later signs: impaired consciousness, nystagmus, muscle twitching, hyperflexia, convulsions, cardiac arrhythmias, hypotension, impaired renal fxn
A
lithium toxicity
8
Q
excreted in urine 95%
dehydration leads to increase absorption of lithium
A
lithium
9
Q
drugs that increase blood lithium levels
A
thiazides
NSAIDS
ACEI
