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Pharm Block 4 > Anti convulsants > Flashcards

Anti convulsants Flashcards

1
Q

tx for partial - simple or complex seizures

A

valproic acid
phenytoin
Carbamazepine
lamotrigine

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2
Q

tx for general tonic clonic

A

valproic acid
phenytoin
Carbamazepine
lamotrigine

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3
Q

general absence

A

ethosuxmide

valproic acid

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4
Q

tx for status epilepticus

A

IV lorazepam

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5
Q

NTs make too much excitation

A

glutamate

aspartate

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6
Q

Its make to little inhibition

A

gaba

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7
Q

block Na ch and glutamate receptors and NMDA receptors

A

felbamate

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8
Q

used to seizures

SE: aplastic anemia and liver damage

A

felbamate

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9
Q

increases Gaba release

inhibits glutamate release by blocking N type Ca ch presynaptically

A

gabapentin

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10
Q

used in seizures, neuropathic pain (shingles)

A

gabapentin

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11
Q

blocks axonal Na ch in inactivated state

A

phenytoin

Carbamazepine

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12
Q

used in seizures

induces p450
zero order kinetics - dose dependent

A

phenytoin

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13
Q

SE: CNS depression, gingival hyperplasia, hirsutism, osteomalacia, megaloblastic anemia, aplastic anemia,

teratogenic - cleft lip and palate

A

phenytoin

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14
Q

used in seizures and bipolar

DOC for trigeminal neuralgia

A

Carbamazepine

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15
Q

induces p450

SE: CNS depression, agranulocytosis, osteomalacia, megaloblastic anemia, aplastic anemia, exfoliative dermatitis, increase ADH (hyponatremia)

teratogenic - spina bifida and cleft lip and palate

A

Carbamazepine

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16
Q

blocks Na ch
inhibits gaba transaminase
blocks T type Ca ch

A

valproic acid

17
Q

used in absence seizures, mania in bipolar, migraine prophylaxis

A

valproic acid

18
Q

inhibits p450 only anti convulsants

A

valproic acid

19
Q

SE: hepatotoxicity, thrombocytopenia, pancreatitis, alopecia

Teratogenic- spina bifida

A

valproic acid

20
Q

blocks T type Ca ch in thalamic neurons

DOC for absence seizures

A

ethosuximide

21
Q

K inhibitor

A

retigabine

22
Q

AMPA inhibitor
blocks Na ch and glutamate receptors
SE: SJS

A

lamotrigine

23
Q

SVA inhibitor

A

levetiracetam

24
Q

AMPA inhibitor
blocks Na and glutamate and enhances GABA activity
used in migraine prophylaxis
SE: weight loss

A

topiramate

25
Q

Irreversibly inhibits GABA transaminase (decrease gaba degradation)

A

vigabatrin

26
Q

inhibits gaba reuptake

A

tiagabine

Pharm Block 4 (18 decks)

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