Anti psychotics Flashcards
thought disorder
hallucinations
delusions
bizarre behavior
positive symptoms
increase dopamine
mesolimbic
flatten affect poverty of speech loss of feeling social withdrawal amotivation
negative symptoms
decrease dopamine
mesocortical
tx for tourettes
pimozide
haloperidol
fluphenazine
tx for acute dystonia
diphenhydramine
benztropine
trihexyphenidyl
MOA of akathisia
D2 receptor sensitization
syndrome caused by high potency drugs haloperidol and fluphenazine
parkinson like syndrome
tx of drug induced Parkinsonism
anti muscarine: benztropine and trihexyphenidyl
rare cases - amantadine
tx for tardive dyskinesia
decrease dose
switch to atypical (quetiapine or clozapine)
stop all drugs with anti muscarinic property
diazepam
hyperthermia muscle rigidity autonomic instability altered consciousness slow onset no clonus
neuroleptic malignant syndrome
tx for NMS
dantrolene
diazepam
bromocriptine
levodopa
low potency typicals
Chlorpromazine
thioridazine
SE: EPS, urinary retention, sedation, postural hypotension, failed ejaculation, toxic confusional state, corneal and lens deposits is common
Chlorpromazine
SE: EPS, urinary retention, sedation, postural hypotension, cardiotoxcity - torsades, retinal deposits
thioridazine
SE: EPS, urinary retention, sedation, postural hypotension, lasts 6 weeks given as IM depol
fluphenazine
SE: EPS, urinary retention, sedation, postural hypotension, most likely to cause NMS and TD
haloperidol
high potency typicals
Haloperidol
fluphenazine
Atypicals
clozapine olanzapine risperidone aripirazole quetiapine - sedation ziprasidone
SE: EPS, M block, sedation, A block
blocks D2c and 5HT2
Agranulocytosis, weight gain, increased salivation, seizures
clozapine
SE: EPS, M block, sedation, A block, weight gain
blocks 5HT2, improves - symptoms
olanzapine
SE: EPS, M block, sedation, A block, hyperprolactinemia
blocks 5HT2, improves - symptoms
risperidone
SE: low risk EPS, M block, sedation, A block
partial agonist of D2; blocks 5HT2
effective against + and - symptoms of schizo
aripiprazole
