Anti psychotics

Question 1

thought disorder
hallucinations
delusions
bizarre behavior

Answer 1

positive symptoms
increase dopamine
mesolimbic

Question 2

flatten affect
poverty of speech
loss of feeling
social withdrawal 
amotivation

Answer 2

negative symptoms
decrease dopamine
mesocortical

Question 3

tx for tourettes

Answer 3

pimozide

haloperidol
fluphenazine

Question 4

tx for acute dystonia

Answer 4

diphenhydramine

benztropine
trihexyphenidyl

Question 5

MOA of akathisia

Answer 5

D2 receptor sensitization

Question 6

syndrome caused by high potency drugs haloperidol and fluphenazine

Answer 6

parkinson like syndrome

Question 7

tx of drug induced Parkinsonism

Answer 7

anti muscarine: benztropine and trihexyphenidyl

rare cases - amantadine

Question 8

tx for tardive dyskinesia

Answer 8

decrease dose
switch to atypical (quetiapine or clozapine)
stop all drugs with anti muscarinic property
diazepam

Question 9

hyperthermia 
muscle rigidity 
autonomic instability 
altered consciousness 
slow onset 
no clonus

Answer 9

neuroleptic malignant syndrome

Question 10

tx for NMS

Answer 10

dantrolene

diazepam
bromocriptine
levodopa

Question 11

low potency typicals

Answer 11

Chlorpromazine

thioridazine

Question 12

SE: EPS, urinary retention, sedation, postural hypotension, failed ejaculation, toxic confusional state, corneal and lens deposits is common

Answer 12

Chlorpromazine

Question 13

SE: EPS, urinary retention, sedation, postural hypotension, cardiotoxcity - torsades, retinal deposits

Answer 13

thioridazine

Question 14

SE: EPS, urinary retention, sedation, postural hypotension, lasts 6 weeks given as IM depol

Answer 14

fluphenazine

Question 15

SE: EPS, urinary retention, sedation, postural hypotension, most likely to cause NMS and TD

Answer 15

haloperidol

Question 16

high potency typicals

Answer 16

Haloperidol

fluphenazine

Question 17

Atypicals

Answer 17

clozapine
olanzapine
risperidone
aripirazole
quetiapine - sedation
ziprasidone

Question 18

SE: EPS, M block, sedation, A block

blocks D2c and 5HT2

Agranulocytosis, weight gain, increased salivation, seizures

Answer 18

clozapine

Question 19

SE: EPS, M block, sedation, A block, weight gain

blocks 5HT2, improves - symptoms

Answer 19

olanzapine

Question 20

SE: EPS, M block, sedation, A block, hyperprolactinemia

blocks 5HT2, improves - symptoms

Answer 20

risperidone

Question 21

SE: low risk EPS, M block, sedation, A block

partial agonist of D2; blocks 5HT2

effective against + and - symptoms of schizo

Answer 21

aripiprazole