Local Anesthesia Flashcards
metabolized by tissue and blood - pseudochol (butyrylchol)
less than 1 min
esters
procaine
cocaine
benzocaine
metabolized by liver amides and liver dz effect
1.5-2 hrs
amides
lidocaine
bupivacaine
mepivacaine
nerve fibers most sensitive to blockade
small diameter and high firing rates
order of sensitivity
type B and C
type A delta
type A beta and gamme
type A alpha
decrease LA absorption in systemic circulation
prolong effects and decrease toxicity
coadmic of alpha 1 agonists
site of injection
intercostal
caudal
brachial plexus
sciatic nerve
SE: neurotoxicity, septic meningitis, cardiovascular toxicity, allergies
LA
intrinsically causes vasoconstriction by blocking NE uptake
cocaine
tx for LA CNS effects
diazepam
midazolam
propofol
most cardiotoxic
bupivacaine
tx for cardiotoxic
lipid emulsion
less cardiotoxic
levobupivacaine
ropivacaine
