Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm Block 4 > Hypothalamic > Flashcards

Hypothalamic Flashcards

1
Q

secreted from anterior pituitary

associated with JAK tyrosine

A

somatotropin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

responsible for long bone growth

A

IGF-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

stimulates the liver to produce IGF-1
anabolic effects in muscle
catabolic effects in adipose tissue, reduced adiposity, increase muscle mass

A

Somatotropin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

useful in GH def and idiopathic short stature, increasing growth in Turner syndrome, increasing growth in Prader Willi syndrome

A

Somatotropin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

malignancy, papilledema, visual disturbances, GH replacement therapy can cause diabetes mellitus

used in chronic renal failure

A

toxicity of somatotropin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

treats growth failure due to severe IGF-1 deficiency

can cause hypoglycemia

A

mescasermin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

causes acromegaly and gigantism

A

GH secreting pituitary adenoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

treats acromegaly and gigantism, VIPoma, carcinoid tumors, insulinoma, glucagonoma, gastronome, and can control bleeding of esophageal varices

A

octreotide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

inhibits secretion and production of GH

A

octreotide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

ADR: GI side effects, nausea, vomiting, abdominal pain, causes steatorrhea

A

octreotide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

blocks GH receptor (antagonists)

treats acromegaly

toxicity: increase liver enzymes

A

pegvisomant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

blocks oxytocin receptor
decreases uterine contractions
given IV

used: tocolysis for preterm labor
toxicity: increase rates of infant death

A

atosiban

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

released from posterior pituitary

activates V receptors coupled by Gq

A

ADH/ vasopressin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

causes vasoconstriction and increased BP

used to control variceal or colonic bleeding

SE: HTN, bradycardia

A

ADH activates V1 receptor on vascular smooth muscles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

causes translocation of aquaporin 2 to the apical membrane and reabsorption of free water

used in central DI

A

ADH activates V2 receptor on basolateral membrane in collecting duct

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

treats nephrogenic DI

A

thiazides

17
Q

treats lithium induced nephrogenic DI

A

amiloride

18
Q

high specificity for V2 receptor

effects: kidney to decrease excretion of water, acts on extra renal V2 receptor to increase factor 8 and von willebrand factor

A

desmopressin

19
Q

treats con willebrand dz, central DI, hemophilia A, night enuresis

A

desmopressin

20
Q

causes hyponatremia

A

desmopressin

21
Q

caused by overproduction of ADH

characterized by low blood sodium caused by tumor or injury

A

SIADH

22
Q

treatments for SIADH

A

demeclocycline

convipatan

23
Q

antagonist of vasopressin V1A and V2 receptor
increase renal excretion of water
txs SIADH

A

convipatan

tolvaptan

24
Q

no fluids for 8 hrs
after 8 hrs desmopressin is admin

results: normal person after test urine osmotic >750

DI urine osmotic <300 after tes

  • central DIL urine osmotic increase after AVP
  • nephrogenic DI: urine osmp not changed by AVP
A

water deprivation test

Pharm Block 4 (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions