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Neuro > Mood and anxiety disorder pharmacology > Flashcards

Mood and anxiety disorder pharmacology Flashcards

1
Q

What is the prototype SSRI?

A

Fluoxetine

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2
Q

Fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, and escitalopram belong to which class of antidepressants?

A

SSRIs

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3
Q

What is the prototype SNRI?

A

Venlafaxine

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4
Q

Venlafaxine, desvenlafaxine, duloxetine, levomilnacipran, and milnacipran belong to which class of antidepressants?

A

SNRIs

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5
Q

Buproprion is an orphan drug of which class of antidepressant?

A

“Amphetamine-related”

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6
Q

Which antidepressant is a 5-HT1a/alpha 1 partial agonist?

A

Buspirone

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7
Q

What is the prototype 5-HT2 /alpha 2 antagonist?

A

Mirtazepine

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8
Q

Mirtazepine and trazodone belong to which class of antidepressant?

A

5-HT2/alpha 2 antagonists

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9
Q

What is the prototype tertiary amine TCAD?

A

Amitryptyline

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10
Q

Amitryptyline, imipramine, clomipramine, and doxepin belong to which class of antidepressants?

A

Tertiary amine TCADs

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11
Q

What is the prototype secondary amine TCAD?

A

Nortyptyline

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12
Q

Nortyptyline, desipramine, and amoxapine belong to which class of antidepressants?

A

Secondary amine TCADs

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13
Q

What is the prototype MAOI?

A

Tranylcypromine

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14
Q

Tranylcypromine, seligiline, phenelzine, and isocaboxazid belong to which class of antidepressants?

A

MAOIs

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15
Q

Which anticonvulsants are used to control manic symptoms of bipolar disorder?

A

Valproate, carbamazepine, and oxycarbazepine

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16
Q

Valproate, carbamazepine, and oxycarbazepine are used to control what symptoms in bipolar disorder?

A

Manic symptoms

17
Q

Which anticonvulsant are used to control depressive symptoms of bipolar disorder?

A

Lamotrigine

18
Q

What is the prototype antipsychotic used to control psychotic symptoms of bipolar disorder?

A

Olanzepine

19
Q

Olanzepine, quetiapine, lurasidone, and aripriprazole belong to which class of drug?

A

Antipsychotics

20
Q

What is the neurotrophic hypothesis of depression?

A

Glucocorticoids depress the synthesis of BDNF, which decreases neurogenesis (especially in the dentate gyrus)

21
Q

What is the monoamine hypothesis of depression?

A

An imbalance in NE/DA systems and 5-HT systems influence each other neurophysioloically; depressants result from an imbalance between these systems

22
Q

What is the mechanism of action of SSRIs?

A

Block reuptake of 5-HT via the 5-HT transporter in serotonergic nerve terminals

23
Q

What is the mechanism of action of SNRIs?

A

Block reuptake of 5-HT via the 5-HT transporter in serotonergic nerve terminals AND block reuptake of NE via NE transporter in noradrenergic nerve terminals

24
Q

Do SNRIs have a greater affinity for NE or 5-HT transporters?

A

5-HT transporters

25
Q

What is the mechanism of action of buproprion?

A

Enhances NE and DA release at noradrenergic nerve terminals

26
Q

What is the mechanism of action of buspirone?

A

Partial agonist at 5-HT1a receptors and weak alpha 1-adrenergic partial agonist on postsynaptic neurons

27
Q

What is the mechanism of action of mirtazepine and trazodone?

A

Antagonist at 5-HT2 receptors, alpha 2 adrenergic receptors, and H1 receptors on noradrenergic and serotonergic nerve terminals

Neuro (11 decks)

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