Monoclonal Antibodies Flashcards
1
Q
What are monoclonal antibodies?
A
Monovalent antibodies which bind to the same epitope
2
Q
What are features of monoclonal antibodies?
A
Specific
Can be targeted against almost any cell-surface receptor
3
Q
How do monoclonal antibodies work?
A
Bind with cell surface receptors
- either activate signalling in cell
- or inhibit signalling in cell
Bind to induce cell death
Internalisation - antibodies delivering toxins to cancer cells
Block inhibitory effects on T cells
4
Q
What are side effects of monoclonal antibodies?
A
Facial flushing
N+V
