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Immune System > Cytokines > Flashcards

Cytokines Flashcards

1
Q

What are the main cytokines?

A

Interleukins
TNF-a
Interferon-γ

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2
Q

What are the main interleukins?

A 
IL-1
IL-2
IL-3
IL-4
IL-5
IL-6
IL-8
IL-10
IL-12
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3
Q

What is the main source of IL-1?

A

Macrophages

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4
Q

What is the function of IL-1?

A

Acute inflammation

Induces fever

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5
Q

What is the main source of IL-2?

A

Th1 cells

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6
Q

What is the function of IL-2?

A

Stimulates growth and differentiation of T cells

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7
Q

What is the main source of IL-3?

A

Activated T helper cells

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8
Q

What is the function of IL-3?

A

Stimulates differentiation and proliferation of myeloid progenitor cells

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9
Q

What is the main source of IL-4?

A

Th2 cells

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10
Q

What is the function of IL-4?

A

Stimulates proliferation and differentiation of B cells

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11
Q

What is the main source of IL-5?

A

Th2 cells

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12
Q

What is the function of IL-5?

A

Stimulate production of eosinophils

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13
Q

What is the main source of IL-6?

A

Macrophages

Th2 cells

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14
Q

What is the function of IL-6?

A

Stimulates differentiation of B cells

Induces fever

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15
Q

What is the main soruce of IL-8?

A

Macrophages

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16
Q

What is the function of IL-8?

A

Neutrophil chemotaxis

17
Q

What is the main source of IL-10?

A

Th2 cells

18
Q

What is the function of IL-10?

A

Inhibits cytokine production

19
Q

What is the main source of IL-12?

A

Dendritic cells
Macrophages
B cells

20
Q

What is the function of IL-12?

A

Activates NK cells and stimulates differentiatin of naïve T cells in TH1

21
Q

What is the main source of TNF-a?

A

Macrophages

22
Q

What is the function of TNF-a?

A

Induces fever

Neutrophil chemotaxis

23
Q

What is the main source of Interferon-γ?

A

Th1 cells

24
Q

What is the function of Interferon-γ?

A

Activates macrophages

Immune System (9 decks)

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