Type 3 Hypersensitivity Flashcards
What is type 3 hypersensitivity?
Immune complex mediated
What is involved?
Immune complexes between IgG and IgM
What are the targets?
Soluble antigens
How is tissue damage caused?
Deposition of immune complexes in tissues
What factors affect immune complex pathogenesis?
Complex size
Host response
Local tissue factors
What happens to small immune complexes?
Cleared by RES system
What happens to intermediate size immune complexes?
Host unable to clear
What happens to large immune complexes?
Cleared by complement system
What are some disease caused by type 3 hypersensitivity?
Rheumatoid arthritis
Glomerulonephritis
SLE
What is the antigen in RA?
Fc portion of IgG
What is the antigen in SLE?
Ds-DNA
What are the symptoms of SLE?
Low grade fever
Malar rash
Photosensitivity
How can type 3 hypersensitivity be managed?
Anti-inflammatory drugs
Monoclonal antibodies
