Monday 1 - licht - stimulants

Question 1

At low doses, sympathomimetics do this:

medium doses:

high doses:

Think mechanism

Answer 1

low: increase release of NE and DA
med: block NE and DA reuptake
high: inhibits monoamine oxidase (MAO) activity

Question 2

Tx for acute toxicity from sympathomimetics

Answer 2

Antipsychotics

Acidify patient’s urine (this makes more of the drug in the ionized state and make reuptake by the kindeys less common)

Question 3

Should you use amphetamines to get a patient to keep breathing?

Answer 3

NO

Question 4

Two medically acceptable uses for amphetamines according to this guy

Answer 4

ADHD

narcolepsy

Not ok: weight loss

Question 5

Sx of acute sympathomimetic toxicity

Answer 5

cardiac arrhythmias, coronary and cerebral thrombosis

impairs in utero brain development

Question 6

What recreational drug directly stimulates 5HT autoreceptors, which can lead to overheating “on the dance floor”

Answer 6

MDMA

Question 7

drug may be used in helping opening up PTSD patients

Answer 7

MDMA

Question 8

3 types of Xanthines

Answer 8

caffeine
modafinil
armodafinil

Question 9

Proposed mech of Xanthines

Answer 9

• translocation of intracellular Ca from the sarcoplasmic reticulum
• Inhibition of phosphodiesterase (elevated cAMP,)
• Nonselective adenosine receptor agonist (inhibits sleepiness-inducing adenosine)

but these only happens to a significant amount in test tubes at extreme concentration. we don’t really know why it works

Question 10

Theraputic use of Xanthines

Answer 10

cardiac stimulation in CHF (controversial)

used with ergot alkaloids for migrane