Module 9 ML-2 Flashcards
What is the extrinsic ability to influence SV
sympathetic regulation
What does sympathetic stimulation of the ventricles do
increases contracility by increasing calcium release at an given EDV
Explain the sympathetic stimulation
-at rest only 30% of cardiac tropinin is bound with calcium
-so the stimulation increases the L calcium current and makes more calcium in the cytosol and more troponin saturation
What does the increased of L calcium channels do
quicker rise to peak force
higher peak force
faster decline dir to faster reuptake of calcium in SR which preserves diastolic time
Where does the symp stimulation of ventricles occur
in both ventricular and atrial contractile cells because both cells have beta 1 receptors
Phosphorlyation will increase the force which increases…
contractility
Inotropic
changing contractility and stroke volume
How does sympatheic regulation change the baseline control values
ESV: 35
EDV: 135
SV: 100
-phosphorylated proteins give us a bigger stroke volume
Increased contractility leads to what
increased EF
Typical EF
50-75%
Sympathetic EF
80-90%
Weak failing EF
25%
When the para releases Ach onto M-ACH receptors what are the affects on SA, AV, and Atrial cells, ventricular muscle and atrial kick and SV
Sa: decreased HR
AV: decreased conduction rate
Atrial muslce: decreased contractility
Ventricular muscle: no significant effect
atrial kick and SV: decrease
why does the atrial kick and SV decrease when para fires
no AcH repceptors on the lower parts of the heart (ventricles)
When symp releases norepi onto adrenegic receptod how does that affect the SA, AV, atrial muscle, ventricular muscle, atrial kick and SV
SA: increased HR
AV: increased conductionr ate
Atrial muscle: increased contraciltiy
Ventricular muscle: increased contractility
atrial kick and SV: icrease
