Module 8: The Muscular System Flashcards
Fascia
Dense sheet or broad band of irregular connective tissue
Lines the body wall and limbs
Supports and surrounds muscles and other organs
Three layers of connective tissue extending from fascia
Epimysium
Perimysium
Endomysium
All three may extend to form a tendon
Epimysium
Dense, irregular connective tissue
Encircles entire muscle
Perimysium
Dense, irregular connective tissue
Surrounds groups of 10-100+ muscle fibres
Separates fibres into bundles
Fascicles
Bundles of 10-100+ muscle fibres separated by perimysium
Endomysium
Mostly reticular fibers
Penetrates the interior of each fascicle
Separates individual muscle fibers
Sarcolemma
Plasma membrane of muscle fibres
Myofibrils
Consist of myofilaments
Make up muscle fibres
Sarcoplasmic reticulum (SR)
Encircle each myofibril
Stores calcium
Similar to the endoplasmic reticulum of other cell types
Myofilaments
Involved in contraction
Thick and thin
Thick filaments
Made of myosin
Thin filaments
Made of actin
T tubules (transverse tubules)
Infolding of the sarcolemma that carries the
nerve stimulus into the muscle fibre
5 levels of organization in skeletal muscle
Skeletal muscle Fascicle Muscle fiber (cell) Myofibril Myofilaments
Terminal cisterns
Dilated end scars of the SR
On both sides of the transverse tubule
Release Ca2+ to trigger muscle contraction
Z disc
Narrow, plate-shaped regions of dense protein material
Separate sarcomeres
A band
Darker middle part of the sarcomere
Extends entire length of thick filaments
I band
Lighter, less dense
Contains thin filaments but no thick
Z disc passes through the center
Zone of overlap
At end of A band where thick and thin filaments overlap
H zone
Narrow
At centre of A band
Thick filaments but no thin
M line
Middle of sarcomere
At centre of H zone
Proteins that hold thick filaments together
Three proteins that build myofibrils
Contractile
Regulatory
Structural
Two contractile proteins in muscle
Actin and myosin
Myosin
Main component of thick filaments
Motor protein in all three types of muscle tissue
Holds thick filaments in alignment at M line
Actin
Main component of thin filaments
Two regulatory proteins
Tropomyosin and troponin
Tropomyosin
Covers myosin-binding sites in actin when muscle is relaxed
Troponin
Hold tropomyosin strands in place