MODULE 8: CLINICAL CORRELATION Flashcards
The Retroviridae is a single stranded RNA virus that has this enzyme which converts single-stranded RNA viral genome into double-stranded viral DNA.
Reverse transcriptase
HIV affects cells of the immune system particularly __________.
CD4 or T cells
Reverse transcription occurs in what part of the cell?
A. Mitochondria
B. Nucleus
C. Cytoplasm
D. Cell membrane
C. Cytoplasm
Codes for reverse transcriptase, protease, integrase, and ribonuclease.
A. Env
B. Pol
C. Gag
D. Vif
B. Pol
This enzyme catalyzes the insertion of viral DNA into the host genome to establish infection.
Integrase
Terminates elongation process and prevents acute infection of susceptible cells.
A. NRTI
B. Nonnucleoside inhibitors
C. Protease inhibitors
D. None of the above
A. NRTI
Easily metabolized by cytoP450 system and prone to drug interaction.
A. HAART
B. Nonnucleoside inhibitors
C. Protease inhibitors
D. NRTI
B. Nonnucleoside inhibitors
Inhibits HIV protease which activates precursors of gag-pol and binds to the active site of HIV protease and blocks viral maturation.
A. HAART
B. Protease inhibitors
C. NRTI
D. Nonnucleoside inhibitors
B. Protease inhibitors
Inhibits the formation of initiation complex.
A. Tetracyclines
B. Aminoglycosides
C. Linezolid
D. Quinolones
C. Linezolid
Chloramphenicol inhibits this enzyme.
Peptidyl transferase
Prevents binding of aminoacyl tRNA to the ribosome.
A. Chloramphenicol
B. Tetracycline
C. Quinolones
D. Linezolid
B. Tetracycline
What is the biochemical mechanism of quinolone?
Inhibits DNA gyrase
Pelvic inflammatory disease is caused by these two bacteria?
Neisseria gonorrhea and Chlamydia trachomatis
Function of DNA gyrase.
Formation of helices and regulate breaking and rejoining of the DNA chain.
Type of adenomas that have the highest risk of colorectal adenocarcinoma.
A. Villous
B. Tubular
C. Tubulovillous
D. None of the above
A. Villous
VILLOUS IS VILLAIN!
