Module 4 Flashcards
Define tissue
a group of cells that have a similar embryological origin and are specialized.
What are the 3 embryonic germ layers that form tissues?
ectoderm
mesoderm
endoderm
What is the ectoderm
outer layer
skin cells, neurons, pigment cells
What is the mesoderm
middle layer
cardiac, skeletal, smooth muscle, RBC
What is endoderm
inner layer
lung cell, thyroid cell, pancreatic cell
What are the 4 primary adult tissue types
epithelial
connective
muscle
nervois
What is epithelial tissue
covers body surfaces, lines hollow organs, body cavities, and ducts, forms glands.
provides protection
What is connective tissue
protects and supports the body and organs, binds organs together, stores energy reserves as fat, and provides immunity
What is muscle tissue
responsible for movement and generation of force.
What is nervous tissue
initiates and transmits action potentials that help coordinate body activities, monitors the external environment, and contributes to homeostasis
What is the structure of epithelial tissue
arranged in sheets in single/multiple layers
consists mostly of packer cells with little extracellular material.
many cell junctions
has an apical surface (exposed) and a basal surface (close to the underlying body structures)
What is the function of epithelial cells
protection
filtration
lubrication
secretion
digestion
absorption
transportation
excretion
sensory reception
reproduction
What are the major features of epithelial cells?
nearly completely avascular
all substances that enter the body must cross the epithelium
high capacity for renewal
Describe the classification scheme of epithelia
stratified or simple
squamous, cuboidal, or columnar
psuedostratified columnar (misshapen tall)
Where are simple squamous cells found
where there is little wear and tear
where rapid passage of chemicals is observed
ex. alveoli, lining capillaries, lining body cavities
Where are simple cuboidal cells found?
where secretion and absorption of molecules is observed
ex. lining of kidney tubules and in ducts of glands
Where are simple columnar cells found?
ciliated or non ciliated, found at sites of absorption and secretion
ex. lining the fallopian tubes and parts of the respiratory system
Where are pseudostratified columnar cells found?
have goblet cells that secrete mucous inbetween
ex. respiratory tract
Where are stratified squamous cells found?
protects against abrasion
lines esophagus, mouth, and vagina
Where are stratified cuboidal cells found
protective tissue
sweat glands, salivary glands, mammary glands
Where are stratified columnar cells found
secretes and protects
male urethra, and the ducts of some glands
Where are transitional cells found
allows the urinary organs to expand and stretch
lines bladder, urethra, and the ureters
What is a gland
a single cell or a mass of epithelial cells adapted for secretion
What are endocrine glands?
ductless
their secretory products (hormones) enter the extracellular fluid and diffuse into blood
What do endocrine glands secrete?
hormones
What are exocrine glands?
secrete products into ducts that empty at the surface of the covering and lining of the epithelium or directly onto a free surface
What do exocrine glands secrete?
sweat, mucous, saliva, breast milk
What are the 3 types of exocrine glands
merocrine
apocrine
holocrine
How do merocrine glands secrete?
they release their secretions via exocytosis
ex. eccrine sweat gland
How do apocrine glands secrete?
they pinch off their apical surfaces along with their secretory vesicle
ex. apocrine sweat gland
How do holocrine glands secrete?
they rupture and destroy the entire gland cell
ex. sebaceous glands that lubricate and protect skin and hair
What is a serous type
watery, blood plasma-like secretions rich in enzymes
What is a mucous type
watery to viscous products rich in the glycoprotein mucin
What are the main characteristics of CT
most abundant and widely distributed tissue in body
don’t occur on free surfaces
highly vascular (except cartilage and tendons)
has a nerve supply
dispersed in a matrix
What 3 things make up CT
cells
ground substance
proteins
What is the matrix made of
ground substance and proteins
What 3 categories can CT be classified into
CT proper
Supportive CT
Fluid CT
what is CT proper
loose CT
areolar, adipose, reticular
What is supportive CT
cartilage, hyaline, fibrocartilage, bones
What is fluid CT
blood, lymph
immature cells
-blast
mature cells
-cyte
what do fibroblasts do
secrete fibres and matrix
what do macrophages and histiocytes do
develop from monocytes and are phagocytic
what do mast cells do
produce histamine
what do adipocytes do
store energy
which substances are found in ground substance
hyaluronic acid
chondroitin sulfate
dermaten sulfate
keraten sulfate
What is the structure of mesenchyme
can differentiate into any type of CT cell required
what is the function of mesenchyme
supply the cells needed for replacement and repair after a CT injury
What is the structure of areolar tissue
random, web-like fashion
where is areolar CT found
fills the spaces between muscle fibres, surrounds blood and lymph vessels, and supports organs in the abdomen
what is the function of areolar tissue
represents the CT component of epithelial membranes
What is the structure of adipose tissue
consists mostly of fat storage cells with little extracellular matrix
What is the structure of brown fat
has many mitochondria, which explains its efficiency at metabolizing stored fat
what is the location of white fat
cushions the back of the eye, protects the kidneys
what is the location of brown fat
mainly in the neck and clavicular regions
what is the function of white fat
lipid storage, insulation
what is the function of brown fat
thermogenic
it breaks down fats, releases metabolic heat rather than producing ATP
what is the structure of reticular CT
mesh-like, supportive framework
what is the location of reticular CT
lymphatic tissue, spleen, liver
what is the function of reticular CT
forms the stroma of certain organs, and helps bind together the cells of smooth muscle
What is the structure of dense regular CT
bundles of collagen fibres in a regular, orderly, and parallel arrangement that confers great strength
what is the location of dense regular CT
ligaments and tendons
what is the function of dense regular CT
allow ligaments to return to original length after stretching
what is the structure of dense irregular CT
collagen fibres that are irregularly arranged
usually occurs in sheets
what is the location of dense irregular CT
parts of the body where tensions are exerted in various directions
heart valves, perichondrium, tissue around cartilage, and the peristoneum
what is the function of dense irregular CT
give strength and recoil
what is the structure of elastic CT
consist of elastic fibres and fibroblasts
what is the location of elastic CT
lung tissues and elastic arteries
what is the function of elastic CT
strength and recoil
what is the structure of hyaline cartilage
short and dispersed collagen fibres and contains large amounts of proteoglycans.
surface is clear and smooth
what is the location of hyaline cartilage
rib cage, nose, and covers bones where they meet to form moveable joints
what is the function of hyaline cartilage
allows continued growth until adulthood
makes up a template of the embryonic skeleton before bone formation
what is the structure of fibrocartilage
thick bundles of collagen fibers dispersed through matrix.
no perichondrium
what is the location of fibrocartilage
menisci in the knee joint and the intervertebral discs
what is the function of fibrocartilage
strongest of the 3 cartilages
what is the structure of elastic cartilage
threading network of elastic fibers within matrix
perichondrium present
what is the location of elastic cartilage
external ear
what is the function of elastic cartilage
provides strength and elasticity and maintains shape of certain organs
what is the structure of bone
hardest CT
extracellular matrix consists mostly of collagen fibres embedded in a mineralized ground substance
what is the function of bone
provides protection to internal organs and supports the body
helps provide movement, stores minerals, and houses blood-forming tissue
what are the 2 types of cartilage growth
interstitial (endogenous)
appositional (exogenous)
what is the structure of blood
consists of fluid matrix called plasma and formed elements
what is the function of RBC
transport respiratory gases
what is the function of WBC
involved in phagocytosis, immunity, and allergic reactions
what is the function of platelets
blood clotting
what are teh 3 types of muscle tissue
skeletal
smooth
cardiac
what is the structure of skeletal muscle tissue
long, cylindrical fiber
striated
many peripherally located nuclei
what is the function of skeletal muscle tissue
voluntary movement
produces heat
protects organs
what is the location of skeletal muscle tissue
attached to bones and around entrance points to body (mouth, anus)
what is the structure of cardiac muscle
short, branched
striated
single central nucleus
what is the function of cardiac muscle
contracts to pump blood
what is the structure of smooth muscle
short
spindle-shaped
non striated
single nucleus in each fiber
what is the function of smooth muscle
involuntary movement
moves food
involuntary control of respiration
moves secretions
regulated flow of blood in arteries by contraction
what is the location of smooth muscle
walls of major organs and passageways
what 2 cells is the nervous system composed of
neurons (nerve cells)
neuroglia (protective and supportive cells)
Describe the structure of the basement membrane
epithelial cell
basal lamina (mix of glycoproteins and collagen)(attachment site for epithelial cell)
reticular lamina (secreted by CT beneath)
connective tissue
what is ground substance composed of
GAGs (glycosaminoglycans)
proteoglycans
glycoproteins
what is the most common cell type in areolar connective tissue
fibroblast
what are the 2 cell types that function in bacterial phagocytosis
neutrophilic leukocytes (microphages) and monocytes (macrophages)
What is the unique feature of cartilage as a type of connective tissue?
Cartilage is not innervated and therefore relies on diffusion to obtain nutrients. This causes it to heal very slowly.
it is avascular and its microarchitecture is less organized than bone
what is the epithelial membrane
consists of an epithelial layer and an underlying connective tissue layer.
includes mucous, serous, and the cutaneous membranes
what is the cutaneous membrane
the skin
what is a mucous membrane
line cavities that open to the exterior of the body
they are coated with the secretions of mucous glands
what is a serous membrane
line body cavities closed to the exterior of the body
the peritoneal, pleural, and pericardial cavities
what is a synovial membrane
line joint cavities and produce fluid within the joint
tissue repair can only occur when
inflammation has resolved
what are the 4 cardinal signs of inflammation
erythema
swelling
pain
heat
what is happening during inflammation
histamine and other inflammatory mediators cause increased blood flow to injured tissue through vasodilation
these mediators also cause leaky local blood vessels, causing edema
the swollen tissues squeeze pain receptors
what is a tight junction
apical
basal compartments
no extracellular space between cells
movement of substances between cells is blocked
what is an anchoring junction
stabilize epithelial tissues
strong and flexible connections
common on lateral and basal cell surfaces
what are desmosomes
occur in patches (structural proteins) on inner surface of cells membrane
link to other cells
cadherin
what are hemidesmosomes
link cells to the extracellular matrix (ex. basal lamina)
integrins protein
what are adherens junctions
use either cadherin or integrin depending on if they are connecting to other cells or matrix
have contractile protein actin on the cytoplasmic surface
what is a gap junction
forms an intracellular passageway between the membranes of adjacent cells to facilitate movement of small molecules and ions between the cytoplasm of adjacent cells.
what are the 3 CT fibre types
collagen fibers
elastic fibers
reticular fibers
what are collagen fibers
composed of the protein collagen
very tough and resistant to stretching
found in bone, cartilage, tendons, and ligaments
what are elastic fibers
composed of the protein elastin
provide strength and stretching capacity
found in the skin, blood vessels, and lungs
what are reticular fibers
consist of collagen and glycoprotein
provide support in the walls of blood vessels
form a strong, supporting network around fat cells, nerve fibers, and skeletal and smooth muscle fibers
what is an osteon composed of
lamella
lacunae
canaliculi
cantral (haversian) canal
what is the lamella
concentric rings of matrix consist of mineral ssalts that make bones hard and collagen for strength
what are the lacunae
small spaces between lamellae that contain osteocytes
what are canaliculi
minute canals containing the processes of osteocytes, which provide routes for nutrients and waste transport
what is the haversian canal (central canal)
contains blood vessels and nerves
spongy bone has trabeculae instead of osteons