module 3: pain Flashcards
what is an analgesic?
relieves pain without causing loss of consciousness
what is an opioid?
any drug natural or synthetic that has actions similar to morphine
what is an opiate?
applied only to compounds present in opium
endogenous opioid peptides?
- enkephalins, endorphins, dynorphins
- NT, neurohormones, neuromodulators
- CNS and peripheral tissue
what are opioid receptors?- Mu and Kappa
- opioids dont interact with delta
- Mu receptors: activation linked to physical dependence (analgesica, resp depression, euphoria, sedation)
- Kappa receptors (analgesia, sedation, psychotomimetric effects)
3 classifications of drugs that act at opioid receptors?
- pure opioid agonists
- agonist-antagonist opioids
- pure opioid antagonists
what are pure opioid agonists?
-activate mu and kappa. analgesia, euphora, sedation, resp depression, physical depedence, constipation (codeine)
what are agonist-antagonist opioids?
-antagonize analgesia caused by pure agonist
what are pure opioid antagonists?
-do not produce analgesia or anything. used to reverse resp and CNS depression (nalaxon)
other strong opioids?
none are better than opiods
what are adjuvant analgesics and off-label uses?
- complement the effects of opioids (combination)
- enhance analgesia
- treat side effects caused by opioids
- neuropathic pain
- pain relief= limited and less predictable
antidepressants?
- AMITRIPTYLINE
- can reduce pain or neuropathic origin
- elevate mood
- dosing at bedtime is best
- effects start after 1-2 weeks, max after 4-6
antiseizure drugs?
- can help relieve neuropathic pain
- acute pain such as sharp, darting, burning pain
- GABAPENTIN
marijuana?
- most commonly used illicit drug
- cannabis sativa: the source of marijuana (indian hump plant)
psychoactive component of marijuana?
THC (high lipid solubility), highest concentration in female flowers in the flowering tops
pain is… the 5th..
vital sign