Module 3 Flashcards
Oogenesis
Growth of oocyte
folliculogenesis
growth of follicle that contains oocyte
primordal follicle
first stage of follicle development
preantral follicle
early growing of antral follicle
antral follicle
space in the follicle called antrum
corpus luteum
creates progesterone during pregnancy
gonadotropin
hormones release by anterior pituitary, act on gondas to increase sex hormone production
LH
produce theca cells
FSH
produce granulosa cells
Gnrh
repsonsible for rellease LH and FSH
HPG
hypothalamic pituitary gondal axis
theca cells
produced by LH, produce androgens
granulosa cells
prodced by FSH, converts androgens to estrogens
androgens
sex hormone
progesterone
maintains endometrium of uterus, supporting pregnancy
estrogen
promote oogenesis and ovulation
spematogenesis
production and maturation of sperm
spermiogenesis
spermatids to sperm
sertoli cell
nurse cells
leydig cells
steriodogenic
peritubular
functional compartment of testes that produces androgens
intratubular
functional compartment of testes that produces sperm
seminiferous tubules
production of sperm
ABP
keeps local concentration of testosterone high
spermatogonia
stem cells (first stage of sperm production)
spermatocytes
after meiosis, type b daughter cells form into spermatocytes
spermatids
last stage before sperm
spermatozoa
sperm
rete testis
bundles of seminiferous tubules
efferent ductules
pathway between rete testis and epididymus
testosterone
male sex hormone
pampiniform plexus
heat exchange
infundibulum
where the newly ovulated oocyte is captured
ampulla
facilitation of fertilisation
isthmus
storage of sperm and transport of embryo to uterus
fibriae
little arms that grab on to oocyte
seminal plasma
90% of seminal fluid
seminal vesciles
produce 75% of seminal fluid
bulbo-urethral glands
produce some seminal fluid
prostate
at buttom of bladder
corpora cavernosa
column of erectile tissue- what causes an erection
corpus spongiosum
column of erectile tissue- around urethra
capcitation
prepares sperm to be fertilised
acrosome reaction
allows for potential to fuse with oocyte plasma membrane
zona pellucida
glycoprotein coating on oocyte
cortical reaction
one of the blocks to polyspermy: destroying of sperm binding receptors because Ca2+ surge causes ZP to harden
zygote
fertilisation of sperm and egg
morula
cluster of 16 cells
blastocyst
cluster of 100 cells
inner cell mass
embryoblast- forms the embryo
trophectoderm
trophoblast cells- forms the placenta
syncytiotrophoblast
outer layer on trophoblast cells
cytrophoblast
inner layer of cells on trophoblast cells
epiblast
inner fetus cells of embryoblasts
hypoblast
inner yolk sac of embryoblasts
Oocyte membrane block
Oocyte sperm binding receptors shed
progestin
synthetic progesterone
COC
combination oral contraceptive
POP
progesterone only pill
ART
assisted reproductive tehcnology
IVF
multiple egg implantation
ICSI
single sperm injection
PCOS
systs on ovaries
primary diploid
primary oocyte and spermatocyte
primary haploid
secondary oocyte and spermatocyte
Explain steps in spermatogenesis
Spermatagonium, (mitosis)
Primary spermatocyte (meiosis l)
Secondary spermatocyte (meiosis ll)
Spermatid
Explain steps in Oogenesis
Oogenium (mitosis)
Primary oocyte (meiosis l, arrested in prophase l)
Primary oocyte (meiosis l completed, meiosis ll starts, arrested in metaphase ll)
Secondary oocyte (meiosis ll completed)
Oocyte
Stages of folliculogenesis
Primordial Primary Secondary Early antral Antral Ovulatory Corpus luteum
Hormones in IVF and what they do
FSH- follicle growth
Progesterone- luteul support
GnRH agonist - surpress ovulation
HCG- promote oocyte maturation and ovulation, act as LH
Reasons for using POP
History of;
- Hypertension
- Stroke
- DVT
Purpose of withdrawal bleeding on the pill
A pause in hormones causes a withdrawl of support for the endometrial lining, which causes a bleed. This is to act like a normal period and women keep taking the pill.
Causes of infertility in both genders
Males - Dilation of paniform plexus - increase temp = bad sperm - vas deferens blockage Female - ovarian disfunction - endocrine issues - implantation abnormalities
Why is ICSI becoming more popular
if males are having the fertility issues
Where in the uterine tube does fertilisation occur? What
does the infundibulum do?
Occurs in the Ampulla and the infundibulum grabs the oocyte.
Where does sperm maturation occur
epididymus
whats requried for sperm to be fertile
goes through capacitation
What initiates the acrosome reaction in sperm?
Ca 2+ surge
During fertilisation, what is required to preserve
euploidy in the newly formed zygote?
Ca 2+
Describe the cells within a blastocyst. Which cells will
form the fetus? Which cells will form the placenta?
Blastocyst contains Trophoblast (placenta forming) and Embryoblast.
trophoblast - cytotrophoblast ( inner layer ) and syncitriotrophoblast ( outer layer )
Embryoblast - Epiblast (fetus) and Hypoblast (yolk sac).