Module 2 Cyclin/CDK complex Flashcards
Part 2:
RB is ____ and E2F activates the transcription of the ____ which binds to ____
Partially phosphorylated
CYCLIN E + CDK 2
Part 1:
The first cyclin ____ binds to the ____ and ____ which Phosphorylates _____ that holds the ____
CYCLIN D + CDK 4 and CDK 6
Phosphorylates
RB, RETINOBLASTOMA TUMOR SUPPRESSOR PROTEIN + E2F
Part 3:
____ fully phosphorylates RB, causing the entire separation of E2F
Cyclin E + CDK2
Part 4:
Cyclin E + CDK2 phosphorylates the protein ___ which is supposed to inhibit ____
Simultaneously, the E2F removes the ____ which is a repressor
Both promotes the production of ____ leading into the ___
P27 KIP1
Cyclin D
Cell-cycle responsive element
Cyclin A
S Phase
Part 5:
Cyclin A replaces ____ to bind to ____ to cause the S Phase to progress
The process above causes the production of ___ to cease
Cyclin A binds to ___ so M phase can progress
Cyclin E
CDK2
Pre-replication Complex
CDK 1
Part 6:
Cyclin A phosphorylates ____
Eventually, late in the ___ Cyclin A is replaced by ____ signifying the end of mitosis
E2F
G2 Phase
Cyclin B
Part 7:
Cyclin B binds to ____, which leads to what is called the ____
Cyclin B + CDK 1
Maturation/Mitosis Promoting Factor