Module 18- Blood Disorder part 2

Question 1

What is the most common genetic disorder of the blood?

Answer 1

Sickle Cell Disease

Question 2

Sickle Cell Disease is a ________ form of hemolytic anemia?

Answer 2

hereditary

Question 3

What ethnicities are primarily affected by sickle cell disease?

Answer 3

African American

Mediterranean

Question 4

What test is done to see if you are a sickle cell carrier?

Answer 4

Electrophoresis

Question 5

Signs and symptoms of sickle cell disease start appearing within the first ______mo with ____ and _____ observed?

Answer 5

6
anemia
vasculopathy

Question 6

Sickle cell disease is due to ______ hemoglobin

Answer 6

defective

Question 7

In sickle cell disease fluid ______ results and blood _____ occurs?

Answer 7

viscosity

stasis

Question 8

Due to blood viscosity and blood stasis _____ and ______ can result?

Answer 8

thrombosis

infarction

Question 9

A hematocrit score for a sicle cell pt. can range between ____ and ___%

Answer 9

18

30

Question 10

Normal life span of RBC?

Answer 10

90-120 days

Question 11

Life span of a sickle cell RBC?

Answer 11

10-15

Question 12

Which form of sickle cell disease do children and adolescence have?

Answer 12

Sickle Cell Crisis

Question 13

What do we as clinicians do if someone experiences a sickle cell crisis?

Answer 13

stop tx
call med services
administer oxygen

Question 14

What is the major organ affected in sickle cell disease?

Answer 14

kidney

Question 15

What procedure may provide a cure for young patients with symptomatic sickle cell disease?

Answer 15

allogeneic stem-cell transplant

Question 16

What do sickle cell pts. take daily until age 6 to prevent infection

Answer 16

penicillin

Question 17

You could use a chemotherapy med called ___ to increase ______ thereby decreasing the permanent formation of sickle cells?

Answer 17

hydroxyurea

hemoglobin F

Question 18

There is a decreased ______ and an increased _____ seen radiographically with Sickle Cell Disease?

Answer 18

radiodensity

osteoporosis

Question 19

Sickle Cell Disease can present radiographically as a _____ trabecular pattern appearing as “____ _____” rows with large _____ spaces?

Answer 19

coarse
step-ladder (horizontal)
marrow

Question 20

Sickle Cell pts. will have a generalized ______ of the oral tissues?

Answer 20

pallor

Question 21

______ ______ of the mouth can lead to a sickle cell crisis

Answer 21

periodontal involvement

Question 22

Do we use epi in LA on sickle cell pts.?

Answer 22

low dose

Question 23

Can we use nitrous on sickle cell pts?

Answer 23

yes with oxygen greater than 50%

Question 24

What does polycythemia mean?

Answer 24

increase in number and concentration of RBC above normal

Question 25

Hemoglobin and Hematocrit are increased to more than ____% in polycythemias?

Answer 25

50-55%

Question 26

What are the 3 general categories of polycythemia?

Answer 26

relative primary secondary

Question 27

In relative polycythemia we loose ____ which leads to a corresponding loss of ____

Answer 27

plasma level | RBC's

Question 28

What can cause relative polycythemia (fluid loss)

Answer 28

dehydration diarrhea vomiting sweating

Question 29

In relative polycythemia the ______ of cells increases due to?

Answer 29

concentration | loss of plasma level

Question 30

Which polycythemia is an actual increase in RBC count and hemoglobin value?

Answer 30

Polycythemia Vera (primary polycythemia)

Question 31

What else is elevated in polycythemia vera?

Answer 31

WBC | platelets

Question 32

Blood viscosity ________ in polycythemia vera?

Answer 32

increases

Question 33

Polycythemia Vera is a _____ condition resulting from a _____ disorder in which _____ RBC's proliferate?

Answer 33

neoplastic bone primitive (reticulocytes)

Question 34

The tongue, mucous membranes, and gingiva are what color in polycythemia vera?

Answer 34

purplish-red

Question 35

What is the treatment for polycythemia vera?

Answer 35

chemo radiation phlebotomy

Question 36

Pts should avoid ____ supplements and ____ medications with a history of polycythemia vera?

Answer 36

iron | aspirin

Question 37

Secondary polycythemia is also called ____

Answer 37

erythrocytosis

Question 38

What patients can have a secondary polycythemia?

Answer 38

COPD smokers heart conditions

Question 39

A decrease in the total number of WBC's is termed a?

Answer 39

leukopenia

Question 40

What are the 2 conditions that can lead to leukopenia?

Answer 40

infections | Disease/intoxification of bone marrow

Question 41

What is a rare, serious disease involving the destruction of bone marrow

Answer 41

Malignant Neutropenia

Question 42

What is the term for a malignant neutropenia?

Answer 42

Agranulocytosis

Question 43

What is the most extreme abnormal cause of leukocytosis?

Answer 43

leukemia

Question 44

What is often administered to a patient with lymphocytopenia?

Answer 44

gamma globulins

Question 45

Bleeding disorders can be due to platelet _____ or ______

Answer 45

``` dysfunction numbers (low) ```

Question 46

Where are the clotting factors produced?

Answer 46

liver

Question 47

What is the oldest known hereditary bleeding disorder?

Answer 47

hemophilia

Question 48

What hemophilia is "Classic Hemophilia"

Answer 48

Hemophilia A

Question 49

Hemophilia A is caused by a reduction in the amount/function of factor?

Answer 49

VIII

Question 50

What % of people with hemophilia have type A?

Answer 50

85

Question 51

Hemophilia B is also called " _____ _____"

Answer 51

Christmas Disease

Question 52

Hemophilia B is a deficiency of factor _____

Answer 52

IX

Question 53

Both hemophilia A and B are ___ linked ___ genetic diseases?

Answer 53

X | recessive

Question 54

What disease is characterized by a prolonged bleeding time in the presence of a normal platelet count?

Answer 54

Von Willebrand's Disease

Question 55

Patients with Von Willebrands have a defect in platelet ___ and the ______ pathway?

Answer 55

``` function coagulation ```

Question 56

Extraoral signs of Von Willebrands include?

Answer 56

petechiae of skin

Question 57

What does Hemarthroses mean?

Answer 57

bleeding into soft tissue of joints

Question 58

What is the most common hereditary disorder of platelet function?

Answer 58

Von Willebrand's Disease