Module 15

Question 1

Much of this drug’s pharmacological activity is derived from its two active metabolites, PEMA and phenobarbital:

Answer 1

Primidone

Question 2

A Novel Psychoactive Substance and the metabolite of trazodone:

Answer 2

mCPP

Question 3

For the SSRIs, the major metabolite route for the production of active metabolites:

Answer 3

Demethylation

Question 4

Considered to be the most toxic complication of neuroleptic use:

Answer 4

Neuroleptic Malignant Syndrome

Question 5

Drug-induced movement disorders:

Answer 5

Extrapyramidal Effects

Question 6

Used to treat absence seizures; not effective in the treatment of motor seizures:

Answer 6

Ethosuximide

Question 7

An abnormal, excessive firing of neurons in the gray matter of the brain:

Answer 7

Seizures

Question 8

These drugs have a three-ring structure common to all members of this group:

Answer 8

TCAs

Question 9

Serotonin Syndrome usually occurs in this time frame following taking a new drug:

Answer 9

Hours

Question 10

This is an antidepressant and tobacco-addiction medication:

Answer 10

Bupropion

Question 11

Has become the drug of choice for the treatment of myoclonic seizures and generalized absence seizures:

Answer 11

Valporic Acid

Question 12

Used as an adjunct therapy for partial seizures and used to treat neuropathic pain in adults:

Answer 12

Gabapentin

Question 13

There are _____ subtypes of generalized seizures:

Answer 13

7

Question 14

When used to treat seizures, the therapeutic range is:

Answer 14

15-40 mcg/L

Question 15

A naturally occurring mono-saccharide derived from D-fructose:

Answer 15

Topiramate

Question 16

The most common side effect associated with this anticonvulsant is a rash:

Answer 16

Lamotrigine

Question 17

One significant toxic effect of this drug is aplastic anemia:

Answer 17

Carbamazepine

Question 18

Used to treat generalized tonic-clonic and partial seizures:

Answer 18

Carbamazepine

Question 19

Its main metabolite is HPPH, which is inactive:

Answer 19

Phenytoin

Question 20

Inhibition of the reuptake of _____ or _____ is regarded as an important action for the antidepressant drugs.

Answer 20

5-HT or NE

Question 21

Its mechanism of action is to inhibit GABA transferase:

Answer 21

Vigabatrin

Question 22

What are the 2 metabolites of Clozapine?

Answer 22

norclozapine and clozapine-n-oxide

Question 23

Structural analogue of Clozapine

Answer 23

Quetiapine

Question 24

TCAs are primarily metabolized by?

Answer 24

CYP2D6