Module 11 Flashcards
CO has approximately _____ times greater affinity for Hb than oxygen.
200-300
The addition of _____ reduces oxyhemoglobin and methemoglobin to Hb while leaving COHb unaffected.
Sodium hydrosulfite
%COHb saturations of _____ are considered normal for smokers.
<10%
The presence of a _____ coloration of blood may indicate CO poisoning.
Cherry Red
The primary target organ of CN is the _____:
Brain
CN levels less than _____ are generally considered to be normal levels.
0.26mg/L
CN stops cellular respiration by:
Inhibiting electron transport at the cycochrome c oxidase step
Cyanide metabolite:
Thiocyanate
Blood CN concentrations above ___ are consistent with death.
3 mg/L
Conway cell microdiffusion: CO + palladium chloride = _____
Silver-black mirror color
99% of Pb that is absorbed is bound to:
Hb in red blood cells
The first signs of a headache may appear at this %COHb level:
10-20%
Rhodanese is involved in _____ metabolism.
CN
95% of the body burden for Pb is in _____:
Bone
The most common initial step in CN analysis is:
Acidification of CN
Pb causes increased _____ in the blood.
Zinc protoprophyrin
GC detector(s) that can be used to detect CN:
NPD and ECD
CO intoxication is considered to be the ultimate cause of death are associated with %COHb saturations of:
> 50%
Formation of _____ is an antidote for CN poisoning.
Methemoglobin
Major arsenic metabolite:
DMA
Mee’s Lines are associated with what type of poisoning
As poisoning
Pb causes increased _____ in the urine.
Delta-ALA
Dihalomethane metabolism produces:
COHb
Vitamin B12 metabolism produces:
CN
Potassium CN may be used in the manufacture of:
PCP
Stopping of the Kreb’s cycle leases to accumulation of:
Pyruvic acid
Black or gray line along the gums is associated with what type of poisoning
Pb poisoning
CN antidote:
Nitrite/thiosulfate
Arsenic antidote:
BAL
What does GFAAS stand for?
Graphite Furnace Atomic Absorption Spectrometry
