Module 13

Question 1

Barb: Used to treat migraine headaches

Answer 1

Butalbital

Question 2

Barb: Most immunoassays are designed to detect:

Answer 2

Secobarbital

Question 3

Barb: Used to control seizures

Answer 3

Phenobarbital

Question 4

One of the most important pharmacokinetic characteristics of barbiturates is their ability to:

Answer 4

Induce microsomal liver enzymes

Question 5

Adjustment of the pH to approximately _______ and extraction with an immiscible organic solvent will cause the barbiturates to enter the organic layer.

Answer 5

5-7

Question 6

To treat seizures, a phenobarbital concentration of _______ is consistent with a therapeutic concentration.

Answer 6

15-40 mcg/mL

Question 7

Death following barbiturate intoxication is often due to:

Answer 7

Respiratory failure

Question 8

The _______ barbiturates are used to induce surgical anesthesia:

Answer 8

Ultra short acting

Question 9

This is the major inhibitory neurotransmitter in the brain.

Answer 9

GABA

Question 10

GABA antagonist and benzodiazepine antidote.

Answer 10

Flumazenil

Question 11

Benzodiazepines mediate their CNS depressant activity through this neurotransmitter:

Answer 11

GABA

Question 12

Adjusting the pH to _______ allows extraction of benzodiazepines into an immiscible organic solvent.

Answer 12

9-10

Question 13

Benzodiazepine especially effective in managing panic disorder.

Answer 13

Alprazolam

Question 14

This benzodiazepine is relatively unstable in postmortem specimens due to bacterial and thermal degradation.

Answer 14

Clonazepam

Question 15

Benzodiazepines belong to this category of drugs in a DRE evaluation.

Answer 15

CNS depressants

Question 16

Used for the short term treatment of insomnia.

Answer 16

Temazepam

Question 17

This benzodiazepine is thermally unstable.

Answer 17

Chlordiazepoxide

Question 18

Benzo: Effective in managing acute ethanol withdrawal.

Answer 18

Diazepam

Question 19

Benzo: Can be missed by several commercially available immunoassay screening tests.

Answer 19

Lorazepam

Question 20

Clonazepam undergoes ______ to form 7-Aminoclonazepam.

Answer 20

Reduction

Question 21

This drug is a derivative of imidazopyridine.

Answer 21

Zolpidem

Question 22

Glutethimide is structurally similar to this barbiturate.

Answer 22

Phenobarbital

Question 23

Name the 3 Z Drugs?

Answer 23

Zaleplon, Eszopiclone, Zolpidem

Question 24

What 3 benzos have no active metabolites?

Answer 24

Lorazepam, Oxazepam, Estazolam

Question 25

What drug blocks active of benzodiazepines?

Answer 25

Flumazenil

Question 26

Antianxiety Benzos

Answer 26

Diazepam, Chlordiazepoxide, Oxazepam, Lorazepam, Alprazolam

Question 27

Anticonvulsant Benzos

Answer 27

Diazepam, Lorazepam, Clonazepam, Clobazam, Midazolam

Question 28

Ultra short acting barbs

Answer 28

Thiopental, Thiamylal, Methohexital

Question 29

Short Acting barbs

Answer 29

Pentobarbital, Secobarbital

Question 30

Intermediate Acting barbs

Answer 30

Amobarbital, Butalbital, Butabarbital

Question 31

Long Acting barbs

Answer 31

Phenobarbital