Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Biochem 2 > Mitochondrial > Flashcards

Mitochondrial Flashcards

exam 2

1
Q

What happens to mitochondria after stroke and myocardial infarction?

A

acute loss of them

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

neurodegenaration is related too

A

loss of mito function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

outer membrane is composed of

A

50% protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

inner membrane composed of

A

80% protein, cardiolipin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

outer membrane has _____ channels and is permeable to ________

A

outer membrane has porin channels and is permeable to small molecules (<10 kDA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

inner membrane contains (3)

A

(1) complexes I-IV
(2) ATP synthase
(3) transporters (ANT)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

TCA cycle and beta-oxidation enzymes are

A

nuclear

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

TOM

A

translocases of the outer membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

TIM

A

translocases of the inner membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

mitochondria contain ______ DNA

A

bacterial-like

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

mitochondria has _____ compartments

A

4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

electron transfer by respiratory chain is couples with

A

the transfer of protons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

oxidative phosphorylation

A

production of ATP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

electron transfer from NADH to O2 involves

A

complexes I-IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

generation of the electrochemical proton transmembrane potential involves

A

complexes I, III, IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

use proton motive force to synthesize ATP

A

ATP synthase; complex V

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

reduction potential reflects

A

its affinity for electrons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

final acceptor of electrons

A

O2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

respiratory chain consists of 4 protein complexes that use various _______ to shuttle electrons

A

prosthetic groups

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

prosthetic group IV

A

heme

21
Q

rotenone, Amytal, Piericidin A inhibits

A

Complex I

22
Q

antimycin inhibts

A

complex III

23
Q

carbon monoxide, cyanide, azide inhibits

A

complex IV

24
Q

which complex is not a proton pump?

A

complex II

25
Q

oligomycin

A

inhibitor of ATP synthase

26
Q

the mitochondrial inner membrane is impermeable to

A

NADH/NAD+

27
Q

FADH2 transfers electrons to

A

Q

28
Q

irreversible shuttle

A

glycerol phosphate

29
Q

reversible shuttle

A

malate-aspartate

30
Q

coupling

A

rates of oxygen consumption by respiratory chain and ATP sythesis by ATP synthase are interdependent

31
Q

acute opening of mitochondrial transition pore leads to

A

inner membrane permeability transition- key to stroke and MI!

32
Q

mTDNA has no ____ and only codes for ___ proteins the other are encoded by nuclear DNA

A

introns and only codes fro 13 proteins

33
Q

energy dependent chaperones

A

TOM and TIM

34
Q

pre-sequence peptide in the protein

A

TOM

35
Q

internal sequence peptide in the pre-protein

A

TIM

36
Q

takes proteins inside

A

TOM

37
Q

cells create their own ___, cannot use dietary

A

ATP

38
Q

TCA cycle is an

A

oxidative process of Acetyl CoA

39
Q

Factoid of complexes and their organic complexes/ prosthetic groups

A

complexes do not participate in rxn it is their groups that do the m

40
Q

which complexes if inhibited stops respiration

A

Complexes III and IV

41
Q

IMM is impermeable to

A

NADH/NAD+

42
Q

how are the electrons of NADH transported?

A

Shuttles!!!

43
Q

Glycerol Phosphate shuttle is a ________ enzyme and it is an _____ process

A

it is a complex II enzyme and it is an irreversible process

44
Q

thermogenin protein/UCP1 in brown adipose tissue

A

physiologic uncoupling

45
Q

ANT exports ____ from matrix and imports ____

A

exports ATP and imports ADP.

46
Q

ANT also imports ____ and exports ____

A

imports Pi and exports OH-

47
Q

atractyloside and bongkrekic acid inhibits

A

ANT

48
Q

High calcium triggers _____ which is associated with stroke and MI.

A

MPT

49
Q

CsA binds to CypD and stops PT pores from opening leading to ____ being inhibited

A

MPT

Biochem 2 (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions