Mitochondria Flashcards

1
Q

What types of lifeforms combined via endosymbiosis to eventually give rise to mitochondria?

A

free-living aerobic heterotrophic prokaryotic bacteria was engulfed by an anaerobic archaea

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2
Q

Mitochondria are often ___ like organelles located in the cells of almost all _______

A

rod, eukaryotes

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3
Q

What is one eukaryote that does not have mitochondria?

A

monocercomonoides

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4
Q

Why do people believe mitochondria originated from bacteria?

A

The little amount of DNA they contains is most likely bacterial DNA

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5
Q

What does sequencing of numerous mitochondrial DNA confirm?

A
  • All mitochondria originated from the integration of a eubacterial ancestor into a host cell related to asgard archaea
  • The transition to permanent organelles entailed a massive number of evolutionary changes
  • The above changes occurred incrementally as the endosymbiont and the host became integrated
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6
Q

What is symbiosis?

A

A typically advantageous interaction between two different organisms living in close physical association

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7
Q

How is the archaea and bacteria merging symbiotic?

A

The archaea was anaerobe. By combining with aerobic bacteria, it can do respiration

Bacteria gained protection by living inside archaea

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8
Q

Describe how the DNA of the bacteria and archaea merged gradually over time

A

Each prokaryote has its own set of DNA (a genome). The bacteria’s genome remains
separate (curved blue line) from the archaea’s genome (curved purple line). The bacteria
continued to replicate within the host cell. Over time, during errors of replication or
perhaps when the bacteria lyses and loses its membrane separation from the host, genetic
material becomes separated and merges with the host cell genome. Eventually, the host
genome becomes a mixture of both genomes, and it ultimately becomes enclosed in an
endomembrane, a membrane within the cell that creates a separate compartment. This
compartment eventually evolves into a nucleus.

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9
Q

What are the 4 benefits of the bacteria merging into the archaea?

A
  • Extra energy allowed archaea to focus on other things, like membrane bound organelles and a nuclear envelope
  • Specialized functionality for each organelle
  • Mitochondrial division occurred, merging some of it’s DNA into the eukaryotic cell
  • Evolution of the nucleus
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10
Q

What are nuclear pores? What do they do?

A

They are tiny pores in the nuclear envelope. They selectively permit certain macromolecules to enter and leave the nucleus, including RNA

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11
Q

Why are eukaryotic cells able to more intricately regulate protein production?

A

The separation of the DNA from the protein synthesis

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12
Q

How to prokaryotic cells multiply?

A

Binary fission process, since they don’t have a nucleus. It’s fast and hard to control, which is problematic when a cell forms part of a larger organism

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13
Q

What happens when cell replication coordination fails in a multicellular organism?

A

cancer

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14
Q

Cellular respiration gives around __ ATP per glucose molecule while fermentation gives _ ATP

A

30, 2

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15
Q

What is an autotroph and heterotroph?

A

Autotroph: Organism that makes complex org compounds using carbon from substances such as CO2. generally uses light or inorganic chemical reactions

Heterotroph: Organism that cannot produce its own food and consumes autotrophs

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16
Q

What’s the 2nd law of thermodynamics?

A

In a closed system of reactions, entropy increases. Energy is always lost as heat in a reaction

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17
Q

What prevents the universe to disintegrate?

A

Influx of energy from the sun.

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18
Q

What is energy from the sun stored as?

A

Organic molecules such as carbs and fats. Also converted into ATP

19
Q

What is ATP?

A

The energy currency the powers any non-spontaneous reaction

20
Q

What produces ATP?

A

Mitochondria

21
Q

What percentage of ATP do mitochondria supply?

A

~90%

22
Q

What is the process of turning oxygen and food into ATP called?

A

Cellular respiration

23
Q

~1890, who showed strings of granules in cells and called them bioblasts?

A

Richard Altmann

24
Q

When did Carl Benda coin the term mitochondria?

A

1898

25
Q

When and who linked mitochondria to cellular respiration?

A

1913, Otto Heinrich Warburg. From guinea-pig liver

26
Q

When and who discovered cytocrhomes?

A

1925 David Keilin

27
Q

Around what time did scientists discover that mitochondria could produce ATP and that one oxygen atom produces 2 ATP molecules

A

1930s and 40s

28
Q

Describe the mitochondria’s structure according to 1952 information

A

Surrounded by outer membrane

Inner membrane folds inwards to form cristae, which are surrounded by the fluid matrix

29
Q

What are 2 byproducts from cellular respiration?

A

Water and CO2

30
Q

When and who proposed the chemiosmotic theory for ATP production

A

1960, Peter Mitchell

31
Q

What is Chemiosmosis

A

movement of ions (charged particles) across a semipermeable membrane, down their electrochemical gradient

32
Q

What is ATP synthase?

A

Enzymes located on the inner membrane of the mitochondria that create ATP molecules

33
Q

How does ATP synthase make ATP?

A

Via the movement of hydrogen ions across the membrane during cellular respiration. H+ ions are moved from a region of high concentration (space between membranes) to low concentration (matrix)

34
Q

Describe the electron transport chain and how ATP is generated

A

Refer to slide 5-32

The citric acid cycle help pump H+ into the intermembrane space, which is then used to produce ATP

35
Q

What kinds of cells can require lots of ATP and have about 1000-2000 mitochondria per cell

A

Muscle and Liver tissue cells

36
Q

Describe mitosomes, aerobic mitochondria, anaerobic mitochondria, and hydrogenosomes

A

mitosomes: Do not generate ATP
aerobic mitochondria: Uses O2 to make energy
anaerobic mitochondria: Do not produce H2
hydrogenosomes: Do not possess electron transport chain

37
Q

What functions do mitochondria serve besides energy production

A

Heat production (protons re enter matrix without making ATP. This generates heat)
Storage of calcium ions
Regulation of cellular proliferation
Involved in Apoptosis

38
Q

What are mitochondrial diseases?

A

Inherited disorders caused by dysfunctional mitochondrial

39
Q

Where do mitochondrial diseases hit the hardest. Why?

A

Muscles, brain, digestive system, and kidneys as they all use lots of energy

40
Q

What are symptoms of mitochondrial diseases?

A
  •   poor growth
  •   loss of muscle coordination, muscle weakness
  •   visual and hearing problems
  •   learning disabilities
  •   heart, liver, kidney diseases
  •   gastrointestinal and respiratory disorders
  •   neurological problems
  •   autonomic dysfunction and dementia
41
Q

What are examples of mitochondrial diseases?

A
  •   diabetes
  •   Huntington’s disease
  •   cancer
  •   Alzheimer’s disease, Parkinson’s disease
  •   bipolar disorder, schizophrenia, anxiety disorders
  •   aging and senescence
  •   cardiovascular disease, chronic fatigue syndrome
42
Q

Describe Parkinson’s disease

A

A neurological disorder caused by diminished energy production, which affects neuron function. In addition, calcium ion homeostasis is also disrupted

43
Q

How is mitochondria linked to the aging process?

A

Mitochondrial dysfunction and disruption of the balance between the generation of new and removal of damaged mitochondria is linked to the aging process.