Minerals Flashcards
which minerals belong to the macromineral group
calcium magnesium sodium potassium (sulphur, chloride, iron)
what minerals belong to the micromineral group
chromium cobalt copper fluoride iodine iron manganese selenium zinc
what is the main role of minerals
- bone: 25% ash, 36% Ca, 17% P, 0,8% Mg
- teeth: fluoride
- hair, wool, hooves: S-aminoacids and others
- soft tissues
- blood elements: Fe, Ca, Co
functional support of minerals
- maintain acid-bace balance: na, k, ca, mg, cl
- maintain osmotic balance: sodium, potassium, chloride
- facilitate the transfer of nutrients across cell membranes: na, k, ca, mg
- maintain proper nerve conduction: na, ca, k, mg
- help to contract and relax muscles: ca, mg
- in enzyme systems regulating cellular functions: se – glutathione peroxidase. B12 vitamin
- regulate bodys tissue growth: iodine in T3, T4
- help expression and regulation of genes
calcium
biological function
- bone structure
- blood clotting (prothrombin and thrombin)
- muscle contraction
- neurotransmission
- enzyme activator
- egg production: 2g ca per egg ca
- neutralizes acidity
calcium
what are the general deficiency diseases
acute hypocalcemia
chronic hypocalcemia
calcium and phosphorous deprevation
calcium
deficiency in ruminants
Ruminants: hypocakcaemia
ruminants: milk fever
calcium
ruminant hypocalcemia
- decreased GI and rumen motility - risk of abdominal displacement
- decreased appetite - fat mobilization, ketosis
- decreased muscle contractability - closing of teats - risk of mastitis
- downer cow syndrome
calcium
ruminant milk fever
high yealding older lactating cows
- 48 hrs after calving
- Muscular weakness, circulatory failure, muscle twitching
- Anorexia, rumen stasis
- Convulsions or tetany
calcium
hypocalcemia in Ca, Fe
Ca, fe: hypocalcemia
- Postpartum eclampsia / puerpera tetany
- Prior to birth
- Underactive parathyroid gland
- Calcium supplementation during pregnancy
- Inadequate Ca:P ratio in diet during pregnancy
- Muscle tremors, tetany, convulsions
cacium
equine hypocalcemia
Equine hypocalcemia
- Sweat
- Diaphragmatic flutter: endotoxaemia, endurance horses
- Lactation tetany: 2 weeks before delivery – weaning
- Transport tetany
- Blister beetle toxicosis
calcium
where is it found
Forages – legumes – alfalfa
Milk and milk replacers
(cereals are low)
calcium
control of supply
feedstuff
chloride
biological function
- main EC anion
- always together with na or k – cellular pump function
- production of HCl in stomach
chloride
daily requirements
Bo: 2-2,5 g/kg DM
Ov: 1,8-2,5 g/kg
Su: 2-3 g
DM 0,3% of daily feed ration
chloride
deficiency
Hyperchloremia - metabolic alkalosis
- horse: endurance exercise – sweating
- ruminants: abomasal displacement
chloride
where is it found
Fish and meat meal – not to food producing animals
Grass: 0,03
magnesium
biological function
- enzyme activity
- metabolism of carbohydrates, fats, proteins, nucleic acids
- cell membrane functions
- neurotransmission
- increase alkalinity
- processing ATP
magnesium
daily requirements
Bo: 0,7-2,5 g/kg DM
Ov: 1,2-1,8 g/kg
Sus: 0,4 g
magnesium
deficiency
Inflammation – SIRS: low mg
Neurotransmission: low resting membrane potential- convulsions
Insulin resistance
Decreased PTH production - hypocalcemia
Grass tetany / winter tetany/ calf tetany
magnesium
grass tetany
Grass tetany / winter tetany/ calf tetany:
- lactating beef cow in pasture: spring grass: low mg, ruminal acidosis and high pasture K decrease absorption of Mg in forestomach, parallel hypocalcemia common
- winter: poor quality feed
- calves: milk replacers
magnesium
where is it found
Mineral supplement: mgo, mgco3, mgso4
Alfalfa
magnesium
control of supply
Serum levels
Absorption
Excretion
- feces, urine
phosphorous
biological function
- formation and maintenance of bone
- deoxy- and ribonucleic acid component
- cell membrane formation
- osmotic and acid base balance maintenance
- ATP
- Fatty acid transportation, amino acid and protein synthesis
- Sodium / potassium ion pomp activity
phosphorous
deficiency
Hyperphosphatemia - Cell lysis Hypophosphatemia - Refeeding syndrome: Hyperinsulinemia/hyperglycemia P goes into cell - Haemolysis - Rhabdomyolysis - Nervous system
phosphorous
where is it found
Grains – cereals
Lesser amounts: green forages, legumes, mineral supplement
Mineral supplements
phosphorous
control of supply
Absorption: small and large intestine
- Decreased: phytate
- Increased vitamin D
Excretion: Feed Urine
potassium
biological function
- Main IC ion – systemic electrolyte
- Highest concentration in muscle
- Coregulating ATP with sodium
potassium
daily requirements
Bo: 6,5-10 g/kg
Ov: 5-8 g/kg
Sus: 1,7-2,8 g
potassium
deficiency
Rare
Loss of appetite
Wekness
Ru: high K in close up dry cows feed, increase risk of milk fever
potassium
where is it found
Forages – feed of plant origin
potassium
control of supply
Short term control: serum, insulin
Long term: urine, sweat ruminants
sodium
biological function
- Main EC cation – systemic electrolyte
- Homeostatic control
- Coregulating ATP with potassium
sodium
daily requirements
Bo: 1-1,9 g/kg
Ov: 0,9-1,8 g/kg
Sus: 1,5-2 g
DM 0,15-0,2 % NaCl supplementation of daily ration
sodium
hyponatremia
acute low serum Na
chronic low Na intake
sodium
acute low serum Na
Acute low serum Na:
- Behavioural abnormalities, vomiting, convulsions, decreased consciousness
- Causes: dehydration: vomit and diarrhe, euhydration: Addison or SIDAH, hyperhydration: renal insufficiency
sodium
chronic low Na intake
Chronic low Na intake
- Pica, cannibalism in broilers
- Pu pd
- Weight loss
- Limiting milk production
sodium
hypernatremia
Hypernatremia
High na: thirst, disorientation convulsions, PU
- Dehydratin: heat stress, sweat, burns
- Euhydration: diabetes insipidus, salt toxicosis
- Hyperhydraton: cushings
sodium
where is it found
Feed of animal origin – fish meal
plant origin does not have enough
sodium
control of supply
Excretion: Faeces, saliva, saliva, sweat
cobalt
biological function
- Part of vitamin B12
2. Enzyme activator: methyl-malonyl-CoA cholesterol synthesis
cobalt
daily requirements
1% Co supply (long release bolus)
- Only required in ruminants where rumen bacteria produce B12
cobalt
deficiency
Growth depression – ruminants
Anemia
White liver disease - sheep
cobalt
overdose / toxicity
rare
Toxicosis: fatty liver, pneumothorax
Polycytemia in monogastric animals
cobalt
where is it found
Legumes
Plants, yeasts, molasses, coprophagy
copper
biological function
- Ligaments and tendons
- Activity of mitochondrial enzymes (redox) cytochrome c
- Melanin synthesis
- Mobilization of iron storage
copper
deficiency
Bound to ceruloplasmin in cell and blood
- Copper deficiency- decreased ceruplasmin
- Transformation deficient: fe2+ fe3+ anemia
Wool structure and pigment loss
Damage in the foetal nervous system
Increased bone fragility
Foal: developmental orthopaedic disease
- Eg. Osteochondrosis dissecans
- Chronic inflammation copper deficiency
copper
toxicosis
Calves:
- Very high abs from milk
- Administration of coccidiostat antibiotics increase absorp
Sheep (calves):
1. Pre haemolytic stage: Cu fills up liver storage – no clinical signs
2. Haemolytic phase: liver overloaded, stress, liver damage, copper to blood damage on blood cells
copper
where is it found
Cereals in concentrate feed is better than supply from forage
Forages: bound to vegetable lipids
Grains: dicotyledons sunflower
copper
control of supply
hair
fluorine
biological function
- Formation of tooth enamel – fluoroapatite crystal
2. Bones and teeth
fluorine
deficiency
rare
fluorine
toxicity
Accumulation in
- Discoloured teeth, bone
fluorine
where is it found
High water content or phosphate supplements have high fluoride
1-4 mg/kg
fluorine
control of supply
Storage in bone and teeth
Excreted in urine
iodine
biological function
- Development of nervous system
2. Biosynthesis of thyroxine
iodine
deficiency
Deficiency in certain geographical areas
Water nitrate contamination, goitrogen plant
Goiter, myxedema, difficult reproduction (abnormal foetus, abortion)
iodine
where is it found
Forages
Drinking water 3-10 ug/kg
iodine
control of supply
Milk
75% bound to tyrosine in thyroid gland in the hormones
iron
biological function
- Constituent of haemoglobin and myoglobin
- Active part of catalase, peroxidase and cytochrome P450
- O2 delivery
iron
deficiency
Piglet: low level in sow colostrum anemia, cardiac hypertrophy
Calves: less common
Rare in adult animal
Chronic diseases: apparent Fe deficiency (blood loss iron def)
iron
toxicity
Parenteral iron treatment - Cannot limit absorption - Antioxidant pretreatment - Hepatocellular necrosis Enteral: - Chronic: immunosuppression - Free radicals, oxidizing lipids and antioxidants
iron
where is it found
Plant feeds
iron
control of supply
Storage: liver, bone marrow
manganese
biological function
- Synthesis of mucopolysaccharides and cartilage
- Stimulation of denovo cholesterol synthesis: important in females – ovaries produce steroids
- Cofactor for antioxidant enzymes – superoxide dismutase
manganese
deficiency
Developmental abnormalities of the skeletal system
- Part of glucosyl transferase system cartilage development
- Perosis: slip of achilles tendon, calcaneous deformity
Reproduction:
- Alimentary fertility – number of female foetuses decrease
manganese
where is it found
Monocotyledon: grasses – sour grass
Dicotyledons: lower amount - alfalfa
manganese
control of supply
Storage: liver (skin, muscle, bone)
Faeces
Hair: 7 mg/kg
molybdenum
biological function
where is it found
Required for xanthine oxidase and related oxidases
forages
nickel
biological function
present in urease
selenium
biological function
- Antioxidant with E-vitamin or separately
2. Glutathione peroxidase
selenium
deficiency
Secondary hypothyroidism: De dependent deiodases
Broilers: exudative diathesis
Foals, caves, lambs: white muscle disease
Equine nutritional muscle dystrophy
Swine VESD: vitamin E selenium deficiency syndrome
- Hepatic necrosis, esophageal-gastric ulcer and multberry heart
selenium
toxicity
Vitamin E + se supplements Se accumulating plants – astragallus sp. Acute: - Eq: blind staggers – ataxia, dyspnoe - Ov: garlic odor of expired air Chronic: “alkali disease” - Eq: cracked hooves, hair, tail loss + liver and renal degeneration, lameness
selenium
where is it found
Forages and grains
selenium
control of supply
Hair
Enzyme activity glutathione peroxidase
sulfur
biological function
- Minor constituent of fats, body fluids, skeletal minerals
- Key component in most proteins - contained in the amino acids methionine and cysteine
- Enzyme cofactor
sulfur
daily requirements
Cattle: 0,20 of DM
- Dairy: S:N ratio 1:10
- Beef: S:N ratio 1:15
- Sheep: S:N ratio 1:7
sulfur
deficiency
Deficiency: hair and wool
sulfur
toxicity
Toxicity:
- Ammonium sulphate neurological signs
- Brassica species containing s-dimethyl sulfoxide haemolytic anemia
sulfur
where is it found
Forages and grains
sulfur
control of supply
Excretion: renal
zinc
biological function
- 80 diff zinc-metalloenzymes (carboxypeptidase, liver-alcohol dehydrogenase, carbonic anhydrase)
- 20 enzymes activated by zinc
- Transport of vitamin A is dependent on zinc, zn defA def
zinc
daily requirements
40-80 mg/kg DM
zinc
deficiency
Parakeratosis: swine and certain ruminants Problem in reproductive function Decreased taste, decreased VDMI Chronic disease cause deficiency Canine parakeratosis:
zinc
canine parakeratois
- Cereal grain- high phytate, low free fatty acid
- Generic malabsorption in northern breeds
- Lethal acrodermatitis in bull terrier
zinc
overdose
Decreased copper, secondary Fe deficiency
zinc
where is it found
legumes
zinc
control of supply
faeces
hair