Miles - Chemo Agents

Question 1

Cell Cycle Specific Drugs

Answer 1

Only targets proliferating cells

Question 2

Cell Cycle Non-specific Drugs

Answer 2

Goes after proliferating and non-proliferating cells

Question 3

Specific Chemo Agents

Answer 3

AntiMet
Topo 1
Mitotic

“AntiMetMiteTop1”

Question 4

Non-Specific Chemo Agents

Answer 4

Alkylating
Topo 2
Antitumor/Cytotoxic Antibiotics
Monoclonal

Everything NOT ANTIMETMITETOP1

Question 5

Alkylating Agents

Answer 5

Non Specific

Covalent bond w/DNA, RNA, Proteins

Kill cells in various phases

Question 6

Antimetabolites

Answer 6

Cell Cycle Specific

Compete w/normal metabolite for catalytic or regulatory site of key enzyme or by substitution of metabolite that is normally incorporated into DNA and RNA

Most effective during S-phase

Question 7

Topoisomerase Inhibitors

Answer 7

Block topoisomerases

Topo 1 = Cell cycle specific
Topo 2 = Not cell cycle specific

Question 8

Anti-microtubule Agents (antimitotic)

Answer 8

Cell cycle specific

Stabilize microtubule dynamic, stop anaphase

Effective at S and M phase

Question 9

Antitumor (cytotoxic) antibiotics

Answer 9

Not cell cycle specific

Insert between base pairs of DNA and RNA; inhibit synthesis

Question 10

Monoclonal Antibodies

Answer 10

Not cell cycle specific

Slow down out of control (Attenuate growth signals, inhibit angiogenesis)

Speed up normal response (create immune response)