Miles - Cancer Bio 1 Flashcards

1
Q

Benign

A

Expansive, slow growth, differentiates, does NOT metastasize

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2
Q

Adenoma

A

Benign epithelial neoplasm

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3
Q

Lipoma

A

Benign mesenchymal neoplasm

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4
Q

Malignant

A

Infiltrative, fast growth, poor differentiation, metastasize

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5
Q

Carcinoma

A

90% of cancer, 80% of deaths

Malignant epithelial neoplasm

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6
Q

Malignancy of cells that serve protective functions

A

Basal Cell Carcinoma

Squamous Cell Carcinoma

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7
Q

Malignancy of cells that secrete substances into ducts or cavities

A

Adenocarcinoma

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8
Q

Sarcoma

A

Malignant mesenchymal neoplasm

Solid tumor of connective tissue (except blood)

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9
Q

Lymphoma/Leukemia

A

Malignant neoplasm of lymphoid cells

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10
Q

How do tumors usually start?

A

Hyperplastic lesion which undergoes metaplasia

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11
Q

Dysplastic Lesions

A

Abnormal structure/function

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12
Q

Growth Process: Hyperplasia

A

Hyper Genesis = proliferation of cells; growth or enlargement

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13
Q

Growth Process: Metaplasia

A

Adaptive substitution of one cell type for another (pre-malignant change, replaced by more capable tissue under stress)

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14
Q

Growth Process: Dysplasia

A

Abnormality in cell size, appearance, with or without a disorganized growth pattern (ex polyps)

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15
Q

Metastatic Growth

A

Once growth invades other tissues

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16
Q

Growth Process: Neoplasia

A

Disease of cells characterized by alteration of normal growth regulator mechanisms–activation of uncontrolled signaling cascades

17
Q

Growth Process: Desmoplasia

A

Formation and proliferation of connective tissue in response to neoplastic growth (angiogenesis?)

18
Q

Tumor Viruses: DNA Genome

A
Hepatitis B
SV40/Polyomavirus
Papillomavirus
Adenovirus
Herpes Virus
19
Q

Tumor Viruses: RNA Genomes

A

Hepatitis C

Retrovirus

20
Q

What are the principle causes of liver cancer?

A

Hep B/Hep C

Chronic infections prior to cancer

21
Q

Papillomavirus

A

Small DNA virus

Infect epithelial cells; some cause benign (warts) others cause carcinoma

Pap smear test

22
Q

What two herpesviruses cause human cancer?

A

Kaposi’s Sarcoma

Epstein-Barr

23
Q

Retrovirus

A

Cause of adult T-Cell leukemia

24
Q

What are the three levels of cancer prevention?

A

Primary - Avoiding Carcinogens

Secondary - Early diagnosis

Tertiary - Reducing recurrence or spreading

25
Q

Are cancer deaths increasing, decreasing, or staying the same?

A

Increasing

26
Q

How does cancer usually kill?

A
  1. Occlusion of essential duct (e.g. colon, broncial)

2. Mass causes dysfunction from replacement of the substance of a parenchymatous organ (e.g. brain, hepatic)

27
Q

What are early warning signs of cancer?

A
Lump
Sores that won't heal
Weight loss
Effusion
Fever
Fatigue
Unusual bleeding
28
Q

What type of disease is cancer?

A

A progressive disease

29
Q

What are the two steps of the cancer process?

A

Tumor Initiation

Tumor Progression

30
Q

Clonal Selection

A

Mutations which give tumor an advantage

31
Q

What are 6 properties of cancer?

A
  1. Angiogenesis
  2. Self-sufficiency in growth signals
  3. Insensitivity to anti-growth signals
  4. Evasion of apoptosis
  5. Limitless replicative potential
  6. Tissue invasion and metastasis
32
Q

Uncontrolled Proliferation

A

Autocrine Growth stimulation present

Cancer cells do NOT display contact inhibition

33
Q

Insensitivity to Antigrowth Signals

A

Cancer cells do not exhibit density dependent inhibition

34
Q

When is angiogenesis required for tumors?

A

As tumor size increases beyond 2mm