migrane

Question 1

what is the premonitory phase?

Answer 1

the earliest stage of a migrane

small changes in homeostasis (sleep, hunger, mood)
can lead to activation of the hypothalamus and the midbrain
which excites cortical neurons

this excitment makes the
light seem brighter,
sounds louder,
odours overwhelming

Question 2

What is the Aura phase?

Answer 2

this is after the premonitory phase when cortical spreading depression CSD occurs and leads to huge depolarizations which leads to high extracellular K+. and lots of unregulated glutamate (stimulatory)

lead to lots of neuroexcitability
-blind spots
-confusion
-pins and needles on skin

Question 3

CSD

Answer 3

cortical spreading depression

Question 4

what are the 3 phases of a migrane?

Answer 4

1 premonitory phase
2 aura phase
3 headache phase

Question 5

What is the headache phase?

Answer 5

most intense part of a migraine caused by the activation of the trigeminal sensory pathways

The headache phase is the most debilitating stage, involving intense pain and heightened sensory sensitivity.

light = pain
sound = pain

Question 6

activation of the ____ lead to the headache phase of a migrane

Answer 6

trigeminal sensory pathways

Question 7

acute treatment vs. preventitve treatment vs. Emerging treatment

Answer 7

acute treatment: relieves or reduces the severity of a migraine once it has started. (ibuprofen) (Triptans)

preventative treatment: before they start. (Beta-blockers)(anti-depressants)

emerging treatment: antagonists

Question 8

is increased corical excitability genetic sometimes?

Answer 8

yes

Question 9

How does Familial Hemiplegic Migranes effect cortical spreading depression?

Answer 9

People with familial hemiplegic migranes are more suceptable to CSD