MIDTERMS: Parkinson's Disease Flashcards
Stiffness due to simultaneous contraction of opposing muscles, causing resistance to passive movement.
Rigidity
: Slowness of movement, difficulty initiating movements, and reduced arm swing and foot shuffling when walking.
Bradykinesia
Stooped posture, difficulty maintaining balance, and increased fall risk.
Postural Instability
Postural Instability
Resting “pill-rolling” tremors, typically starting in one hand, diminishing during voluntary movement and sleep, but progressing with the disease.
Tremors
Two sybgroups of Parkinson’s
Postural Instability Gait Disturbed (PIGD)
Tremor-Predominant (fewer issues with bradykinesia or postural instability).
What are the non-motor symptoms of Parkinson’s Disease?
Cognitive deficits: Dementia, bradyphrenia (slowed thinking).
Autonomic dysfunction: Excessive sweating, constipation.
Sleep disturbances: Insomnia, REM sleep disorder.
Pathophysiology of Parkinson’s Disease
Caused by the degeneration of dopaminergic neurons in the substantia nigra.
Results in reduced dopamine levels.
Lewy bodies are present in affected neurons.
Clinical symptoms only manifest after 30%-60% of neuron loss.
Motor Planning Issues in Parkinson’s Disease
Start hesitation
Freezing episodes
Poverty of movement
Impaired motor learning
Motor Function Impairments in Parkinson’s Disease
Masked face
Micrographia
Fatigue
Contractures & deformities
Impaired gait
Dysarthria
Dysphagia
Akathisia
Postural Issues in Parkinson’s Disease
Kyphotic posture
Increased risk of falls
Characteristics of Rigidity in Parkinson’s Disease
Increased resistance to passive motion regardless of speed
Felt in both agonist and antagonist muscles
Cogwheel and Leadpipe types of rigidity
Begins in shoulders/neck, progresses to face and extremities
Leads to contractures and postural deformities
Bradykinesia Features
Slowness of movement
Reduced speed, range, and amplitude of movements
Contributes to masked facial expression and micrographia
Decreased arm swing while walking
Cardinal Features of Parkinson’s Disease
Rigidity
Bradykinesia
Tremors
Postural Instability
Postural Instability in Parkinson’s Disease
Narrowing base of support
Rigidity and decreased trunk ROM
Stooped posture due to weakness of trunk extensor muscles
Hoehn & Yahr Classification of Disability in Parkinson’s Disease
(meaning of each stage 1-5)
Stage 1: Unilateral symptoms
Stage 2: Bilateral symptoms, no balance impairment
Stage 3: Balance impairment, still independent
Stage 4: Severe disability, can walk/stand unassisted
Stage 5: Wheelchair-bound or bedridden
What is the gold standard pharmacological treatment for Parkinson’s Disease (PD)?
Carbidopa/Levodopa.
Clinical Course of Parkinson’s Disease
Progressive with preclinical phase of 5-25 years
Mean duration of 10-20 years
Patients with PIGD subtype show more rapid progression
Unified Parkinson’s Disease Rating Scale (UPDRS)
(meaning of each part i-iv)
Part I: Non-motor experiences (e.g., mood, cognitive function)
Part II: Motor experiences (e.g., speech, eating)
Part III: Motor exam (e.g., rigidity, bradykinesia)
Part IV: Complications of therapy (e.g., dyskinesias)