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Micro 1 > Midterm Review > Flashcards

Midterm Review Flashcards

1
Q

Defect in RAG1 and RAG2
No T cells
No B cells
Oral candida

A

*OMENN Syndrome

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2
Q

Bruton’s kinase (BtK) deficiency

A

Low/no B cell
B cell stops at pre-B cell

*VDJ rearrangement + mu

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3
Q

B cells normal
No T cells
Chronic candidas of the skin and mucus membranes

A

*DiGeorge

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4
Q

deficiency in CD40L (CD154), CD40, AID

A

No isptype switch
No B cell activation
No A PC activation

  • Hyper IgM
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5
Q

NBT test

Deficiency in NADPH oxidase, G6P, MPO, superoxide dismutase

A

*Chronic Granulomatous disease

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6
Q

?

A

*Immunoflorescence assay

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7
Q

Cells found in paracortex

A

*CD4/CD8

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8
Q

Spleen function

A

Blood borne pathogens

*produce antibodies

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9
Q

Antibodies against RBC

A

(complement)

*MAC lysis

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10
Q

Dark urine

A

Paroxysmal Nocturnal Hemoglobinuria
Lysis of RBC

*CD59/DAF (CD55) deficiency

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11
Q

deficiency in Factor H & Factor I

A

depletion of c3

*increased complement activation

uncontrolled infections

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12
Q

TLR4

A

*gram negative LPS

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13
Q

patient with shock and gram-negative LPS

A

*produces excessive macrophages

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14
Q

cell without MHCI

A

*NK cells

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15
Q

B cell TdT

A

rearranges Heavy chain only

*hasn’t passed PRO-B CELL

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16
Q

immunized person expresses…

A

memory b cells ->

*IgG, IgA, IgE

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17
Q

Positive selection

A

*MHC restriction (MHC+TCR)

double positive

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18
Q

CD3

A

*marker for T cells

signal transducer

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19
Q

T cell lymphoma

A

double negative thymocytes

*CD2

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20
Q

?

A

*vaccine is active and artificial

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21
Q

?

A

*conjugates protein Ab vaccine

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22
Q

disadvantage of live attenuated vaccine

A

*not safe for immunosuppressed individuals

23
Q

SLE

A

(butterfly rash)

  • type 3 HSR
  • deposition f immune complex
24
Q

rheumatoid arthritis + monoclonal antibody

A

serum sickness

*type 3 HSR (and type 4)

25
primary infection (e. Dengue fever)
*IgM
26
FOXP3
*T cell -> Treg
27
mutation in FOXP3
IPEX syndrome - watery diarrhea - eczematous dermatitis - polyendocrinopathy
28
anemia blood > 5 lobes/segments (megaloblastic)
* Intrinsic Factor Deficiency | vit. B12
29
*Tumor Specific Antigen (TSA)
mutated p53, oncoviruses presented by MHCI
30
determines relationship between antigens
*double immunodiffusion assay (ouchterlony) crosses = non-identity no touch = mixture of Ag
31
*Complement Fixation Test
*binds Ag/Ab no RBC lysis = reactive RBC lysed = nonreactive
32
polyclonal T cell activator
*super antigens
33
activates CD8, CD4, NK, B cell proliferation
*IL-2 (CD25)
34
*CD28 & B7
second signal in activations naïve T cells by APC no B7 -> T cell stops/nonfunctional (anergy)
35
B cell CD markers
*CD20 CD19, CD10
36
lymphoma
B cell cancer
37
desensitization
*IgE to IgG | block exposure to Ag
38
monoclonal Ab
* human Fc | * mouse Fab
39
B cell Ag presentation
*Ag presenting cells (APC) to Th1 (effector CD4) on MHC2
40
patients gets sick. patient gets sick again. blood tests 1 day post exposure and 2 weeks post exposure. the test 2 weeks post exposure is higher than the test 1 day post exposure... why?
*somatic hypermutation | affinity hypermutation
41
TAP
*cytosolic pathogens ER membrane protein transports peptides from cytoplasm to lumen of ER
42
increased IgE and increased Th2
*increased IL-4
43
patient with leukemia, needs increased granulocytes
*GM-CSF
44
last stage of B cell
*mature B cell
45
*Defect in CD4
?
46
Th1 transcription factor
*T-bet
47
T cell recognizes Ag but no CD28..
no CTLA-4 - > no down regulation of IL-2 - > increased IL-2 - > autoimmunity
48
produced by T-reg stimulates B cells to Ig class switch
*TFG-beta | monoclonal Ab
49
translocation of IgE
increased IL-5 | increased eosinophils eosinophilia
50
*Rhogam
*prevents mother from anti-Rh
51
electrophoresis? | most common Ig
IgG
52
rheumatic fever
b cell cross reactivity
53
transient deficiency in baby
normal
54
infection, no pus
Th1, macrophages

Micro 1 (15 decks)

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