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Micro 1 > Midterm Review > Flashcards

Midterm Review Flashcards

1
Q

Defect in RAG1 and RAG2
No T cells
No B cells
Oral candida

A

*OMENN Syndrome

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2
Q

Bruton’s kinase (BtK) deficiency

A

Low/no B cell
B cell stops at pre-B cell

*VDJ rearrangement + mu

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3
Q

B cells normal
No T cells
Chronic candidas of the skin and mucus membranes

A

*DiGeorge

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4
Q

deficiency in CD40L (CD154), CD40, AID

A

No isptype switch
No B cell activation
No A PC activation

  • Hyper IgM
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5
Q

NBT test

Deficiency in NADPH oxidase, G6P, MPO, superoxide dismutase

A

*Chronic Granulomatous disease

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6
Q

?

A

*Immunoflorescence assay

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7
Q

Cells found in paracortex

A

*CD4/CD8

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8
Q

Spleen function

A

Blood borne pathogens

*produce antibodies

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9
Q

Antibodies against RBC

A

(complement)

*MAC lysis

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10
Q

Dark urine

A

Paroxysmal Nocturnal Hemoglobinuria
Lysis of RBC

*CD59/DAF (CD55) deficiency

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11
Q

deficiency in Factor H & Factor I

A

depletion of c3

*increased complement activation

uncontrolled infections

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12
Q

TLR4

A

*gram negative LPS

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13
Q

patient with shock and gram-negative LPS

A

*produces excessive macrophages

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14
Q

cell without MHCI

A

*NK cells

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15
Q

B cell TdT

A

rearranges Heavy chain only

*hasn’t passed PRO-B CELL

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16
Q

immunized person expresses…

A

memory b cells ->

*IgG, IgA, IgE

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17
Q

Positive selection

A

*MHC restriction (MHC+TCR)

double positive

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18
Q

CD3

A

*marker for T cells

signal transducer

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19
Q

T cell lymphoma

A

double negative thymocytes

*CD2

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20
Q

?

A

*vaccine is active and artificial

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21
Q

?

A

*conjugates protein Ab vaccine

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22
Q

disadvantage of live attenuated vaccine

A

*not safe for immunosuppressed individuals

23
Q

SLE

A

(butterfly rash)

  • type 3 HSR
  • deposition f immune complex
24
Q

rheumatoid arthritis + monoclonal antibody

A

serum sickness

*type 3 HSR (and type 4)

25
Q

primary infection (e. Dengue fever)

A

*IgM

26
Q

FOXP3

A

*T cell -> Treg

27
Q

mutation in FOXP3

A

IPEX syndrome

  • watery diarrhea
  • eczematous dermatitis
  • polyendocrinopathy
28
Q

anemia
blood > 5 lobes/segments
(megaloblastic)

A
  • Intrinsic Factor Deficiency

vit. B12

29
Q

*Tumor Specific Antigen (TSA)

A

mutated p53, oncoviruses

presented by MHCI

30
Q

determines relationship between antigens

A

*double immunodiffusion assay (ouchterlony)

crosses = non-identity
no touch = mixture of Ag

31
Q

*Complement Fixation Test

A

*binds Ag/Ab

no RBC lysis = reactive
RBC lysed = nonreactive

32
Q

polyclonal T cell activator

A

*super antigens

33
Q

activates CD8, CD4, NK, B cell proliferation

A

*IL-2 (CD25)

34
Q

*CD28 & B7

A

second signal in activations naïve T cells by APC

no B7 -> T cell stops/nonfunctional (anergy)

35
Q

B cell CD markers

A

*CD20

CD19, CD10

36
Q

lymphoma

A

B cell cancer

37
Q

desensitization

A

*IgE to IgG

block exposure to Ag

38
Q

monoclonal Ab

A
  • human Fc

* mouse Fab

39
Q

B cell Ag presentation

A

*Ag presenting cells (APC) to Th1 (effector CD4) on MHC2

40
Q

patients gets sick. patient gets sick again.

blood tests 1 day post exposure and 2 weeks post exposure.

the test 2 weeks post exposure is higher than the test 1 day post exposure… why?

A

*somatic hypermutation

affinity hypermutation

41
Q

TAP

A

*cytosolic pathogens

ER membrane protein

transports peptides from cytoplasm to lumen of ER

42
Q

increased IgE and increased Th2

A

*increased IL-4

43
Q

patient with leukemia, needs increased granulocytes

A

*GM-CSF

44
Q

last stage of B cell

A

*mature B cell

45
Q

*Defect in CD4

A

?

46
Q

Th1 transcription factor

A

*T-bet

47
Q

T cell recognizes Ag but no CD28..

A

no CTLA-4

  • > no down regulation of IL-2
  • > increased IL-2
  • > autoimmunity
48
Q

produced by T-reg

stimulates B cells to Ig class switch

A

*TFG-beta

monoclonal Ab

49
Q

translocation of IgE

A

increased IL-5

increased eosinophils
eosinophilia

50
Q

*Rhogam

A

*prevents mother from anti-Rh

51
Q

electrophoresis?

most common Ig

A

IgG

52
Q

rheumatic fever

A

b cell cross reactivity

53
Q

transient deficiency in baby

A

normal

54
Q

infection, no pus

A

Th1, macrophages

Micro 1 (15 decks)

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