Midterm Review Flashcards
Defect in RAG1 and RAG2
No T cells
No B cells
Oral candida
*OMENN Syndrome
Bruton’s kinase (BtK) deficiency
Low/no B cell
B cell stops at pre-B cell
*VDJ rearrangement + mu
B cells normal
No T cells
Chronic candidas of the skin and mucus membranes
*DiGeorge
deficiency in CD40L (CD154), CD40, AID
No isptype switch
No B cell activation
No A PC activation
- Hyper IgM
NBT test
Deficiency in NADPH oxidase, G6P, MPO, superoxide dismutase
*Chronic Granulomatous disease
?
*Immunoflorescence assay
Cells found in paracortex
*CD4/CD8
Spleen function
Blood borne pathogens
*produce antibodies
Antibodies against RBC
(complement)
*MAC lysis
Dark urine
Paroxysmal Nocturnal Hemoglobinuria
Lysis of RBC
*CD59/DAF (CD55) deficiency
deficiency in Factor H & Factor I
depletion of c3
*increased complement activation
uncontrolled infections
TLR4
*gram negative LPS
patient with shock and gram-negative LPS
*produces excessive macrophages
cell without MHCI
*NK cells
B cell TdT
rearranges Heavy chain only
*hasn’t passed PRO-B CELL
immunized person expresses…
memory b cells ->
*IgG, IgA, IgE
Positive selection
*MHC restriction (MHC+TCR)
double positive
CD3
*marker for T cells
signal transducer
T cell lymphoma
double negative thymocytes
*CD2
?
*vaccine is active and artificial
?
*conjugates protein Ab vaccine
disadvantage of live attenuated vaccine
*not safe for immunosuppressed individuals
SLE
(butterfly rash)
- type 3 HSR
- deposition f immune complex
rheumatoid arthritis + monoclonal antibody
serum sickness
*type 3 HSR (and type 4)
primary infection (e. Dengue fever)
*IgM
FOXP3
*T cell -> Treg
mutation in FOXP3
IPEX syndrome
- watery diarrhea
- eczematous dermatitis
- polyendocrinopathy
anemia
blood > 5 lobes/segments
(megaloblastic)
- Intrinsic Factor Deficiency
vit. B12
*Tumor Specific Antigen (TSA)
mutated p53, oncoviruses
presented by MHCI
determines relationship between antigens
*double immunodiffusion assay (ouchterlony)
crosses = non-identity
no touch = mixture of Ag
*Complement Fixation Test
*binds Ag/Ab
no RBC lysis = reactive
RBC lysed = nonreactive
polyclonal T cell activator
*super antigens
activates CD8, CD4, NK, B cell proliferation
*IL-2 (CD25)
*CD28 & B7
second signal in activations naïve T cells by APC
no B7 -> T cell stops/nonfunctional (anergy)
B cell CD markers
*CD20
CD19, CD10
lymphoma
B cell cancer
desensitization
*IgE to IgG
block exposure to Ag
monoclonal Ab
- human Fc
* mouse Fab
B cell Ag presentation
*Ag presenting cells (APC) to Th1 (effector CD4) on MHC2
patients gets sick. patient gets sick again.
blood tests 1 day post exposure and 2 weeks post exposure.
the test 2 weeks post exposure is higher than the test 1 day post exposure… why?
*somatic hypermutation
affinity hypermutation
TAP
*cytosolic pathogens
ER membrane protein
transports peptides from cytoplasm to lumen of ER
increased IgE and increased Th2
*increased IL-4
patient with leukemia, needs increased granulocytes
*GM-CSF
last stage of B cell
*mature B cell
*Defect in CD4
?
Th1 transcription factor
*T-bet
T cell recognizes Ag but no CD28..
no CTLA-4
- > no down regulation of IL-2
- > increased IL-2
- > autoimmunity
produced by T-reg
stimulates B cells to Ig class switch
*TFG-beta
monoclonal Ab
translocation of IgE
increased IL-5
increased eosinophils
eosinophilia
*Rhogam
*prevents mother from anti-Rh
electrophoresis?
most common Ig
IgG
rheumatic fever
b cell cross reactivity
transient deficiency in baby
normal
infection, no pus
Th1, macrophages