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Micro 1 > hypersensitivity types 2, 3, 4 > Flashcards

hypersensitivity types 2, 3, 4 Flashcards

1
Q

Type 2 HSR immune reactant

A

IgG

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2
Q

Type 2 HSR antigen

A

cell or matrix associated antigen

cell surface receptor

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3
Q

Type 2 HSR effector mechanism

A

complement, FCR cells (phagocytes, NK cells)

antibody alters signaling

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4
Q

Type 2 HSR examples

A

Erythroblastosis fetalis (HDNB)

drug allergies

Graves Disease

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5
Q

Type 3 HSR immune reactant

A

IgG

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6
Q

Type 3 HSR antigen

A

Soluble antigen

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7
Q

Type 3 HSR effector mechanism

A

complement, phagocytes

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8
Q

Type 3 HSR examples

A

serum sickness

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9
Q

Type 4 HSR immune reactant

A

Th1 cells

Th2 cells

CTL

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10
Q

Type 4 HSR antigen

A

Soluble antigen

Soluble antigen

cell-associated antigen

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11
Q

Type 4 HSR effector mechanism

A

macrophage activation

eosinophil activation

cytotoxicity

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12
Q

Type 4 HSR examples

A

contact dermatitis, TB

chronic asthma, chronic allergic rhinitis

contact dermatitis

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13
Q

Erythroblastosis fetalis (HDNB)

A

Rh negative mother, Rh positive fetus

first child minimally affected

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14
Q

Erythroblastosis fetalis (HDNB) treatment

A

Rhogam (IgG anti-Rh)

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15
Q

Ab2

A

against hapten modified self antigen: Ag-Ab on cells or on tissue

Type II hypersensitivity

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16
Q

Ab1

A

against the hapten –may lead to soluble Ag-Ab complex

Type III hypersensitivity

17
Q

Type 3 HSR due to

A

deposition of soluble antigen/antibody complexes

18
Q

Type 3 HSR Immune complex (IC)

A

Small immune complex

circulate in blood when IC formation exceeds disposal from circulation

Reaction could systemic or localized

ex. SLE

19
Q

Type 3 HSR diagnosis

A

Results in depletion of complement in serum:

Level of serum C4 level – diagnosis

20
Q

Type 3 HSR : Serum Sickness reactions

A

Direct Immunofluorescent staining

detecting IgG deposition

“Lumpy-bumpy” pattern

21
Q

Type 3 HSR – Localized : Arthus Reaction

A

Localized deposition of IC within the skin

22
Q

Type III HSR :Lung: Hypersensitivity Pneumonitis (HP)

A

Mediated by IgG

Examples:
farmer’s lung, pigeon breeder’s pneumonitis, cheese washer’s lung, mushroom worker’s lung, laundry worker’s lung, etc

23
Q

Type 4 HSR Cell mediated

A

no antibodies involved

24
Q

Type 4 HSR Sensitization stage

A

Tho CD4 to Th1 effector cells (most common)

Naïve CD8 to cytotoxic CD8 cells (less common)

25
Q

Type 4 HSR CD4 vs CD8

A

CD4:
small mol. (ex.nickel)
Presented to naïve CD4 T cells

CD8:
(ex. poison Ivy)

26
Q

Tuberculin Reaction

A

PPD (purified protein derivative) tests exposure to Mycobacterium tuberculosis

Accumulated Th1 and macrophages

27
Q

Persistent Ag

A

If antigen persists tuberculin swelling becomes granuloma

28
Q

Celiac Disease

A

Gluten from wheat

Type IV hypersensitivity

Clinical Features: malabsorption and diarrhea

Micro 1 (15 decks)

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