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Pharm 1 > Midterm > Flashcards

Midterm Flashcards

1
Q

drug biotransformation

A

non-polar to POLAR

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2
Q

pharmacogenomics

warfarin toxicity

A

vitamin k ->
epoxide reductase ->
*CYTO P450

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3
Q

alkalinize urine

A

NaHCO3

*decreases tubular absorption

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4
Q

Vd=

A

dose administered / plasma drug concentration

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5
Q

drug that crosses membrane

A

steroid

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6
Q

EC50 vs Kd

A

EC50 < Kd

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7
Q

IND step in drug development

A

comes after animal studies, but before human studies (phase 1)

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8
Q

thalidomide

A

phecomelia

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9
Q

drug/food interaction

A

effects absorption

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10
Q

arsenic poisoning, black urine

A

Dimercaperol

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11
Q

inhibits ACh

A

Botulinum toxin

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12
Q

Pilocarpine

A

M3 stimulation

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13
Q

organophosphate chemical antagonist

A

Pralidoxime

contraindicated in carbamate poisoning

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14
Q

Timolol

A

Beta blocker

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15
Q

Varenicline

A

agonist at Nicotinic alpha4/beta2

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16
Q

atropine (receptor type)

A

anti-muscarinic receptor

muscarinic antagonist

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17
Q

Benzotropine

A

Parkinson’s Disease

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18
Q

atropine side effect

A

decreased sweating

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19
Q

anti-spasmotic

A

dicyclomine

20
Q

COPD

A

Ipratropium Bromide

21
Q

mydriatic and cycloplegia

A

*test error of refraction

Tropicamide

22
Q

Clonidine

A

*alpha2 agonist

HTN and Renal disease

23
Q

epinephrine

A

biphasic (decreased beta2, increased alpha1)

24
Q

CHF

A

stimulate Beta1

25
Q

BPH

A

alpha1 antagonism (prazosin)

26
Q

alpha selective at bladder trigone

A

Tamsulosin

27
Q

decreases diastolic, but no effect on systolic

A

beta2

28
Q

contraindication for non-selective Beta blocker

A

asthma

29
Q

physiological antagonist of histamine

A

epinephrine

30
Q

1st generation antihistamine

A

crosses BBB

*block H1 in RAAS

31
Q

lanoprost

A

PGF2alpha analogue

32
Q

mechanism of sumatriptan

A

*5HT-1D/1B

migraines

33
Q

loop diuretics Na/K/Cl co-transport side effects

A

alkalosis

34
Q

resistant HTN

A

add Hydrochlorothiazide

35
Q

spirolactone

A

used in Liver Cirrhosis

36
Q

spirolactone causes

A

hyperkalemia

37
Q

diabetes insipidus

A

Desmopressin

38
Q

cardio-selective Beta1 blocker

A

Atenolol

39
Q

calcium channel blockers

A
  • dipines

nifedipine: decreases BP, cardiac use

40
Q

HTN in pregnancy

A

*Labetalol

or methyldopa

41
Q

Postural Hypotension

A

Alpha1 blockers

42
Q 
increases vascular resistance
increases muscle
increases renal
increases MAP
decreases HR
A

NE

43
Q

COPD

A

M3

44
Q

urinary side effects, antimuscarinic

A

COPD

45
Q

affects drug

A

dimished hepatic metabolism

46
Q

?? enzyme induction ??

A

drug-drug interaction

47
Q

inhibits NE

A

cocaine, TCA

Pharm 1 (8 decks)

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