Midterm

Question 1

drug biotransformation

Answer 1

non-polar to POLAR

Question 2

pharmacogenomics

warfarin toxicity

Answer 2

vitamin k ->
epoxide reductase ->
*CYTO P450

Question 3

alkalinize urine

Answer 3

NaHCO3

*decreases tubular absorption

Question 4

Vd=

Answer 4

dose administered / plasma drug concentration

Question 5

drug that crosses membrane

Answer 5

steroid

Question 6

EC50 vs Kd

Answer 6

EC50 < Kd

Question 7

IND step in drug development

Answer 7

comes after animal studies, but before human studies (phase 1)

Question 8

thalidomide

Answer 8

phecomelia

Question 9

drug/food interaction

Answer 9

effects absorption

Question 10

arsenic poisoning, black urine

Answer 10

Dimercaperol

Question 11

inhibits ACh

Answer 11

Botulinum toxin

Question 12

Pilocarpine

Answer 12

M3 stimulation

Question 13

organophosphate chemical antagonist

Answer 13

Pralidoxime

contraindicated in carbamate poisoning

Question 14

Timolol

Answer 14

Beta blocker

Question 15

Varenicline

Answer 15

agonist at Nicotinic alpha4/beta2

Question 16

atropine (receptor type)

Answer 16

anti-muscarinic receptor

muscarinic antagonist

Question 17

Benzotropine

Answer 17

Parkinson’s Disease

Question 18

atropine side effect

Answer 18

decreased sweating

Question 19

anti-spasmotic

Answer 19

dicyclomine

Question 20

COPD

Answer 20

Ipratropium Bromide

Question 21

mydriatic and cycloplegia

Answer 21

*test error of refraction

Tropicamide

Question 22

Clonidine

Answer 22

*alpha2 agonist

HTN and Renal disease

Question 23

epinephrine

Answer 23

biphasic (decreased beta2, increased alpha1)

Question 24

CHF

Answer 24

stimulate Beta1

Question 25

BPH

Answer 25

alpha1 antagonism (prazosin)

Question 26

alpha selective at bladder trigone

Answer 26

Tamsulosin

Question 27

decreases diastolic, but no effect on systolic

Answer 27

beta2

Question 28

contraindication for non-selective Beta blocker

Answer 28

asthma

Question 29

physiological antagonist of histamine

Answer 29

epinephrine

Question 30

1st generation antihistamine

Answer 30

crosses BBB

*block H1 in RAAS

Question 31

lanoprost

Answer 31

PGF2alpha analogue

Question 32

mechanism of sumatriptan

Answer 32

*5HT-1D/1B

migraines

Question 33

loop diuretics Na/K/Cl co-transport side effects

Answer 33

alkalosis

Question 34

resistant HTN

Answer 34

add Hydrochlorothiazide

Question 35

spirolactone

Answer 35

used in Liver Cirrhosis

Question 36

spirolactone causes

Answer 36

hyperkalemia

Question 37

diabetes insipidus

Answer 37

Desmopressin

Question 38

cardio-selective Beta1 blocker

Answer 38

Atenolol

Question 39

calcium channel blockers

Answer 39

• dipines

nifedipine: decreases BP, cardiac use

Question 40

HTN in pregnancy

Answer 40

*Labetalol

or methyldopa

Question 41

Postural Hypotension

Answer 41

Alpha1 blockers

Question 42

increases vascular resistance
increases muscle
increases renal
increases MAP
decreases HR

Answer 42

NE

Question 43

COPD

Answer 43

M3

Question 44

urinary side effects, antimuscarinic

Answer 44

COPD

Question 45

affects drug

Answer 45

dimished hepatic metabolism

Question 46

?? enzyme induction ??

Answer 46

drug-drug interaction

Question 47

inhibits NE

Answer 47

cocaine, TCA