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Pharm 1 > Intro to ANS & Cholinergic Drugs > Flashcards

Intro to ANS & Cholinergic Drugs Flashcards

1
Q

NE effects what receptors

A

A1, A2, B1, B2, B3

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2
Q

Ach effects what receptors

A

M1, M2, M3

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3
Q

NN

A

autonomic ganglia

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4
Q

NM

A

neuromuscular junction

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5
Q

M1

A

Neuronal

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6
Q

M2

A

cardiac

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7
Q

M3

A

all smooth muscles

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8
Q

what has ONLY PARASYMPATHETIC innervations

A

ciliary muscle and gastric glands

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9
Q

what has ONLY SYMPATHETIC innervations

A

blood vessels and spleen

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10
Q

inhibits the breakdown acetylcholine

what does it cause

A

acetylcholine esterase inhibitors

increase in Ach

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11
Q

Botulinum toxin

A

inhibits VAMPs and SNAPs

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12
Q

Hemicholiniums

A

inhibits CHT

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13
Q

Vesamicol

A

inhibits VAT

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14
Q

Cholinergic esters

A

Acetylcholine, methacholine

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15
Q

reversible Anticholinesterases

A

Physostigmine, Neostigmine, Pyridostigmine, Edrophonium (shortest acting)

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16
Q

actions of Ach on heart

A

negative chrono/dromo/iontropic

17
Q

actions of Ach on blood vessels

A

vasoconstriction

18
Q

actions of Ach on smooth muscles

A

GIT: increase peristalsis

Bronchus: constriction

Glands: secretion

Bladder: detrusor contraction, trigone and sphincter relaxation

19
Q

actions of Ach on eye

A

contraction of circular muscles -> miosis

20
Q

Pilocarpine

A

prominent muscarinic action

penetrates cornea: miosis, ciliary muscle contraction, decrease IOP

21
Q

Mushroom poisoning

A

treated with atropine

22
Q

irreversible anticholinesterases

A

organophosphates, Parathion

used as insecticides or pesticides

23
Q

lipid soluble agents

A

produce CNS effects

24
Q

lipid insoluble agents

A

No CNS effects

25
Q

lipid insoluble agents effects on ganglia

A

higher dose causes blockade of transmission

26
Q

lipid insoluble agents effects on CVS

A

bradycardia

hypotension

27
Q

lipid insoluble agents uses

A

Glaucoma (physostigmine)

Myasthenia Gravis (pyridostigmine, neostigmine)

Paralytic ileus (bethanecol)

decurarization (neostigmine)

Belladonna/atropine poisoning (physostigmine)

Alzeheimers (tacrine, rivastigmine, donepezil)

28
Q

organophosphates muscarinic effects

A 
Diarrhea
Urination
Miosis
Bradycardia
Emesis
Lacrimation
Sweating
Salivation
29
Q

organophosphates poisioning

A

Atropine

Pralidoxime

30
Q

signs of adequate atropinization

A

moderately dilated pupils

31
Q

Pralidoxime

A

reactivates acetylcholinesterase

contraindicated in carbamate poisoning

32
Q

decreases aqueous humor formation

A

Timolol
Dipivefrine
Apraclondine
Dorzolamide/Brinzolamide (topical)

33
Q

increases aqueous humor drainage

A

Pilocarpine

Latanoprost

34
Q

Myasthenia Gravis treatment

A

Neostigmine (+atropine for muscarinic side effects)

35
Q

Myasthenia Gravis test

A

Edrophonium test

36
Q

Nicotinic toxicity

A

Varenicline

Pharm 1 (8 decks)

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