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Pharm 1 > Anticholinergic Drugs > Flashcards

Anticholinergic Drugs Flashcards

1
Q

natural sources of atropine

A

Deadly Nightshade (atropa belladonna)

jimson weed

jameson weed

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2
Q

Natural Alkaloids

A

Atropine, Hyoscine (Scopolamine)

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3
Q

Semisynthetic derivatives

A

Ipratropmium bromide

Tiotropium bromide

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4
Q

Quaternary Compounds

A

Glycopyrrolate

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5
Q

Tertiary Amines

A

Dicyclomine

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6
Q

Antiparkinsonian

A

Trihexyphenidyl

Benztropine (Park my Benz)

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7
Q

Atropine effects on CNS

A

anti motion sickness property

Suppresses tremor and rigidity of parkinsonism

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8
Q

Atropine effects on heart

A

Blockade of M2 receptors on SA node: increases HR

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9
Q

Atropine effects on eyes

A

Mydriasis
photophobia
cycloplegia
increased IOP

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10
Q

Atropine effects on glands

A

M3 blockade

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11
Q

Atropine effects on body temperature

A

increased due to inhibition of sweating

children are more sensitive - atropine fever

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12
Q

Ipratropium bromide

A

More effective in COPD than in bronchial asthma

Ipratropium - I Pray I could breath

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13
Q

Dicyclomine

A

Antispasmodic

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14
Q

Oxybutynin

A

urinary bladder

M1/M3

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15
Q

Drotaverine

A

Inhibit PDE4 ->

↑ cGMP & cAMP

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16
Q

glycopyrrolate

A

prevent reflex laryngospasm

17
Q

pirenzepine, telenzepine

A

Peptic Ulcer

18
Q

darifenacin

A

Hyperhydrosis

19
Q

dicyclomine

A

excessive salivation

20
Q

Atropine methonitrate, dicyclomine

A

Intestinal and renal colic

21
Q

loperamide, diphenoxylate + atropine

A

Nervous and drug induced diarrhoea, functional diarrhea

22
Q

oxybutynin, flavoxate

A

Urinary urge incontinence, enuresis

23
Q

Ipratropium bromide & tiotropium bromide

A

COPD

24
Q

mydriatic and cycloplegic: To test error of refraction

A

tropicamide

25
Q

mydriatic and cycloplegic: In Fundoscopy

A

phenylephrine

26
Q

Treatment of iridocyclitis/ iritis/uveitis

A

homatropine

27
Q

cardiac vagolytic

A

atropine

28
Q

Prophylaxis for Motion/Sea sickness

A

hyoscine ***

29
Q

Parkinsonism

A

Benztropine

30
Q

Anticholinesterase (oraganophosphate) poisoning & early type of mushroom poisoning

A

atropine

31
Q

Neostigmine therapy in myasthenia gravis

A

atropine to block muscarinic side effects

32
Q

Major difference between atropine & hyoscine

A

at low doses, atropine is CNS excitant whereas hyoscine is depressant

33
Q

Atropine overdose

A 
Hot as a hare
Dry as a bone
Red as a beet
Blind as a bat
Mad as a hatter
Tachycardia
34
Q

Contraindications of atropine therapy

A

narrow iridocorneal angle

BPH in elderly

Pharm 1 (8 decks)

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