Anticholinergic Drugs Flashcards
natural sources of atropine
Deadly Nightshade (atropa belladonna)
jimson weed
jameson weed
Natural Alkaloids
Atropine, Hyoscine (Scopolamine)
Semisynthetic derivatives
Ipratropmium bromide
Tiotropium bromide
Quaternary Compounds
Glycopyrrolate
Tertiary Amines
Dicyclomine
Antiparkinsonian
Trihexyphenidyl
Benztropine (Park my Benz)
Atropine effects on CNS
anti motion sickness property
Suppresses tremor and rigidity of parkinsonism
Atropine effects on heart
Blockade of M2 receptors on SA node: increases HR
Atropine effects on eyes
Mydriasis
photophobia
cycloplegia
increased IOP
Atropine effects on glands
M3 blockade
Atropine effects on body temperature
increased due to inhibition of sweating
children are more sensitive - atropine fever
Ipratropium bromide
More effective in COPD than in bronchial asthma
Ipratropium - I Pray I could breath
Dicyclomine
Antispasmodic
Oxybutynin
urinary bladder
M1/M3
Drotaverine
Inhibit PDE4 ->
↑ cGMP & cAMP
glycopyrrolate
prevent reflex laryngospasm
pirenzepine, telenzepine
Peptic Ulcer
darifenacin
Hyperhydrosis
dicyclomine
excessive salivation
Atropine methonitrate, dicyclomine
Intestinal and renal colic
loperamide, diphenoxylate + atropine
Nervous and drug induced diarrhoea, functional diarrhea
oxybutynin, flavoxate
Urinary urge incontinence, enuresis
Ipratropium bromide & tiotropium bromide
COPD
mydriatic and cycloplegic: To test error of refraction
tropicamide
mydriatic and cycloplegic: In Fundoscopy
phenylephrine
Treatment of iridocyclitis/ iritis/uveitis
homatropine
cardiac vagolytic
atropine
Prophylaxis for Motion/Sea sickness
hyoscine ***
Parkinsonism
Benztropine
Anticholinesterase (oraganophosphate) poisoning & early type of mushroom poisoning
atropine
Neostigmine therapy in myasthenia gravis
atropine to block muscarinic side effects
Major difference between atropine & hyoscine
at low doses, atropine is CNS excitant whereas hyoscine is depressant
Atropine overdose
Hot as a hare Dry as a bone Red as a beet Blind as a bat Mad as a hatter Tachycardia
Contraindications of atropine therapy
narrow iridocorneal angle
BPH in elderly