Antiadrenergic Drugs

Question 1

Irreversible α Adrenergic blocking agents

Answer 1

phenoxybenzamine

Question 2

Reversible non-selective α Adrenergic blocking agents

Answer 2

phentolamine

Question 3

Reversible selective α Adrenergic blocking agents

Answer 3

** prazosin, terazosin, doxazosin, tamsulosin

Question 4

Phenoxybenzamine

Answer 4

Effects: ↓BP, Tahyadia, Postual hypotension

Use: Pheochromocytoma

ADRs: Postural hypotension, Tachycardia

Question 5

Phentolamine

Answer 5

Use: Pheochromocytoma

ADR: Severe postural hypotension, tachycardia

Question 6

Prazosin, Doxazosin, Terazosin, Tamsulosin (α1A)

Answer 6

Sharp fall of B.P. (except tamsulosin)

** Use: BPH (benign prostatic hyperplasia); BPH + HTN

ADR: postural hypotension

Question 7

α blocker (phentolamine) + Epinephrine

Answer 7

only fall in B P

Question 8

β blocker (propranolol) + Epinephrine

Answer 8

only rise in B P

Question 9

β-Adrenergic Blocking Agents

Answer 9

Drugs with –lol suffix

Question 10

Propranolol effects on blood vessels

Answer 10

Contraindicated in peripheral vascular diseases

Question 11

Propranolol effects on bronchoconstriction

Answer 11

Contraindicated in COPD & bronchial asthma

Question 12

Propranolol effects in insulin dependent DM

Answer 12

Glucose intolerance in prediabetics (↓ insulin release)

↑ VLDL, ↓ HDL

Question 13

Propranolol effects on CNS

Answer 13

used in performance anxiety

Question 14

Propranolol effects on eyes

Answer 14

β2 blockade in the ciliary epithelium- (timolol)

Question 15

Drug interactions of propranolol

Answer 15

With digitalis & verapamil:
cardiac arrest may occur

With insulin & oral hypoglycemics:
more hypoglycemia, warning signs of hypoglycemia are suppressed

With NSAIDs:
↓ i antihypertensive effects of β blockers

Question 16

Hypertension beta blocker

Answer 16

atenolol

Question 17

Glaucoma beta blocker

Answer 17

timolol

Question 18

Migraine beta blocker

Answer 18

propranolol

Question 19

Hyperthyroidism beta blocker

Answer 19

propranolol

esmolol

Question 20

Congestive heart failure (CHF) beta blocker

Answer 20

metoprolol
bisoprolol
carvedilol

Question 21

Propanolol ADR

Answer 21

Bronchoconstriction
Bradycardia
Sexual impairment
Rebound HTN (if withdrawn suddenly in hypertensive patients)

Question 22

Propanolol Contraindications

Answer 22

1. COPD
2. Bronchial asthma
3. Diabetes mellitus & Hyperlipidemia
4. Partial and complete heart block
5. Variant angina
6. Severe heart failure patients (class III & IV)
7. Patients with peripheral vascular disease