Antiadrenergic Drugs Flashcards
Irreversible α Adrenergic blocking agents
phenoxybenzamine
Reversible non-selective α Adrenergic blocking agents
phentolamine
Reversible selective α Adrenergic blocking agents
** prazosin, terazosin, doxazosin, tamsulosin
Phenoxybenzamine
Effects: ↓BP, Tahyadia, Postual hypotension
Use: Pheochromocytoma
ADRs: Postural hypotension, Tachycardia
Phentolamine
Use: Pheochromocytoma
ADR: Severe postural hypotension, tachycardia
Prazosin, Doxazosin, Terazosin, Tamsulosin (α1A)
Sharp fall of B.P. (except tamsulosin)
** Use: BPH (benign prostatic hyperplasia); BPH + HTN
ADR: postural hypotension
α blocker (phentolamine) + Epinephrine
only fall in B P
β blocker (propranolol) + Epinephrine
only rise in B P
β-Adrenergic Blocking Agents
Drugs with –lol suffix
Propranolol effects on blood vessels
Contraindicated in peripheral vascular diseases
Propranolol effects on bronchoconstriction
Contraindicated in COPD & bronchial asthma
Propranolol effects in insulin dependent DM
Glucose intolerance in prediabetics (↓ insulin release)
↑ VLDL, ↓ HDL
Propranolol effects on CNS
used in performance anxiety
Propranolol effects on eyes
β2 blockade in the ciliary epithelium- (timolol)
Drug interactions of propranolol
With digitalis & verapamil:
cardiac arrest may occur
With insulin & oral hypoglycemics:
more hypoglycemia, warning signs of hypoglycemia are suppressed
With NSAIDs:
↓ i antihypertensive effects of β blockers
Hypertension beta blocker
atenolol
Glaucoma beta blocker
timolol
Migraine beta blocker
propranolol
Hyperthyroidism beta blocker
propranolol
esmolol
Congestive heart failure (CHF) beta blocker
metoprolol
bisoprolol
carvedilol
Propanolol ADR
Bronchoconstriction
Bradycardia
Sexual impairment
Rebound HTN (if withdrawn suddenly in hypertensive patients)
Propanolol Contraindications
- COPD
- Bronchial asthma
- Diabetes mellitus & Hyperlipidemia
- Partial and complete heart block
- Variant angina
- Severe heart failure patients (class III & IV)
- Patients with peripheral vascular disease
