Adrenergic Drugs Flashcards
enzyme from Tyrosine to DOPA
hydroxylase
Reserpine
inhibits reuptake of Dopamine
Cocaine, TCA
inhibits reuptake of NE
Metyrosine
inhibits tyrosine hydroxylase
no/weak β3 action
Epinephrine (Adrenaline)
no/weak β2 action
Norepinephrine (Noradrenaline)
no/weak α action
Isoproterenol (Isoprenaline)
α1 receptor
Gq
smooth muscles, glands
contraction, secretion
α2 receptor
Gi
nerve endings
decreased transmitter release
smooth muscle
contraction
β1 receptor
Gs
cardiac muscle
increased HR, renin, force
β2 receptor
Gs
smooth muscle, liver, heart
relax smooth muscle, increased HR and force
nonselective α agonists
NE
α1-selective agonists
phenylephrine
α2-selective agonists
clondine
nonselective β agonists
isoproterenol
β1-selective agonists
dobutamine
β2-selective agonists
albuterol
Vasoconstrictor agents
Phenylephrine
Cardiac stimulants
Dobutamine
Dopamine
Bronchodilators
Albuterol
Nasal decongestants
Phenylephrine
Xylometazoline
CNS stimulants
Amphetamine
Uterine relaxant (Tocolytics)
Ritodrine
α1 effects
↑ TPR
↑ BP
reflex bradycardia
mydriasis
Phenylephrine
nasal decongestant & ophthalmic use
mydriasis without cycloplegia
Methyldopa use
HTN in Pregnancy
Salmeterol, albuterol use
bronchial asthma, COPD
Ritodrine & terbutaline use
premature labor
Norepinephrine (noradrenaline) effects
↑ HR
No β2 effect
Epinephrine (adrenaline) effects
↓TPR
↓ BP- β2
Biphasic response on BP
Dopamine
adrenergic agonist
Use:
cardiogenic (renal vasodilation via D1 receptors) or septic shock & congestive heart failure (CHF)
Fenoldopam use
hypertensive emergency
Dobutamine
selective β1 agonist
Used in severe CHF
Ephedrine
↑ release of NE
use: hypotension
Tachyphylaxis
Amphetamine uses
narcolepsy and attention deficit hyperkinetic
disorder
contraindications for the use of adrenergic agonists
Ischemic heart disease Hypertension Diabetes mellitus Pheochromocytoma Hyperthyroidism
