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Pharm 1 > Adrenergic Drugs > Flashcards

Adrenergic Drugs Flashcards

1
Q

enzyme from Tyrosine to DOPA

A

hydroxylase

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2
Q

Reserpine

A

inhibits reuptake of Dopamine

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3
Q

Cocaine, TCA

A

inhibits reuptake of NE

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4
Q

Metyrosine

A

inhibits tyrosine hydroxylase

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5
Q

no/weak β3 action

A

Epinephrine (Adrenaline)

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6
Q

no/weak β2 action

A

Norepinephrine (Noradrenaline)

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7
Q

no/weak α action

A

Isoproterenol (Isoprenaline)

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8
Q

α1 receptor

A

Gq

smooth muscles, glands

contraction, secretion

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9
Q

α2 receptor

A

Gi

nerve endings
decreased transmitter release

smooth muscle
contraction

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10
Q

β1 receptor

A

Gs

cardiac muscle

increased HR, renin, force

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11
Q

β2 receptor

A

Gs

smooth muscle, liver, heart

relax smooth muscle, increased HR and force

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12
Q

nonselective α agonists

A

NE

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13
Q

α1-selective agonists

A

phenylephrine

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14
Q

α2-selective agonists

A

clondine

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15
Q

nonselective β agonists

A

isoproterenol

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16
Q

β1-selective agonists

A

dobutamine

17
Q

β2-selective agonists

A

albuterol

18
Q

Vasoconstrictor agents

A

Phenylephrine

19
Q

Cardiac stimulants

A

Dobutamine

Dopamine

20
Q

Bronchodilators

A

Albuterol

21
Q

Nasal decongestants

A

Phenylephrine

Xylometazoline

22
Q

CNS stimulants

A

Amphetamine

23
Q

Uterine relaxant (Tocolytics)

A

Ritodrine

24
Q

α1 effects

A

↑ TPR
↑ BP
reflex bradycardia
mydriasis

25
Q

Phenylephrine

A

nasal decongestant & ophthalmic use

mydriasis without cycloplegia

26
Q

Methyldopa use

A

HTN in Pregnancy

27
Q

Salmeterol, albuterol use

A

bronchial asthma, COPD

28
Q

Ritodrine & terbutaline use

A

premature labor

29
Q

Norepinephrine (noradrenaline) effects

A

↑ HR

No β2 effect

30
Q

Epinephrine (adrenaline) effects

A

↓TPR
↓ BP- β2
Biphasic response on BP

31
Q

Dopamine

A

adrenergic agonist

Use:
cardiogenic (renal vasodilation via D1 receptors) or septic shock & congestive heart failure (CHF)

32
Q

Fenoldopam use

A

hypertensive emergency

33
Q

Dobutamine

A

selective β1 agonist

Used in severe CHF

34
Q

Ephedrine

A

↑ release of NE

use: hypotension

Tachyphylaxis

35
Q

Amphetamine uses

A

narcolepsy and attention deficit hyperkinetic

disorder

36
Q

contraindications for the use of adrenergic agonists

A 
Ischemic heart disease
Hypertension
Diabetes mellitus
Pheochromocytoma
Hyperthyroidism

Pharm 1 (8 decks)

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