Mid 2: Drugs for ischemic heart disease Flashcards
Typical angina
-stable angina
atheroscletotic plaque in coronary artery
predictable pain
-unstable angina
rupture of artery plaque causes platelet aggregation and thrombus formation
Variant Angina
caused by vasospasm in coronary artery
Norganic nitrates and nitrates
treat angina thorough vasodilation
release NO to smooth muscle
amyl nitrate
organic nitrate angina treatment
inhaled
nitroglycerin
organic nitrate for angina
nitrated and nitrates adverse effects and tolerance
decreased boodpressure, reflex tachychardia, headache
continuous use leads to reduced visodilative effect (aldehyde dehydrogenase is inactivate by oxygen free radicals)
calcium channel blockers
vasodilators for angina
block L type Ca channels in vasc smooth muscle
dipine suffix
DHP class calcium channel blockers
diltiazem
non-DHP calcium blocker
verapamil
non dhp calcium channel blocker
-olol
beta blockers, used for angina
atenolol
selective b1 blocker
metoprolol
selective b1 blocker
nadolol
non selectve b blocker
propranolol
non selective beta blocker
beta blockers variant angina
cannot be used b/c b blockers have no effect on coronary arteries
Ivabradine
inhibits funny current in SA node to reduce heart rated. used for stable angina and heart failure
ranolazine
treats stable angina by inhibiting late na current in cardiomyocyetes
trimetazidine
antianginal that inhibits beta oxidation for FA metab. Beta exidation uses more o2 than glycolysis so this decreases heart 02 usage
