Final: NSAIDs and inflammation

Question 1

prostaglandins

Answer 1

inflammation

Question 2

arachidonic acid

Answer 2

precursor of prostaglandins

Question 3

aspirin mech

Answer 3

acetylates serine in COX acitve site and blocks acces to arachidonic acid

Question 4

NSAIDs mech

Answer 4

block the opening of both COX-1 and COX-2 by
interacting with Arg 120 in both enzymes in a reversible manner

Question 5

COXibs

Answer 5

block only the opening of the COX-2 enzyme in
an irreversible manner

Question 6

ASA

Answer 6

COX-1 & Cox-2

Question 7

cox 1,2 thrombotic effects

Answer 7

cox 1 produces thrombotic effects b/c platelets (aspirin antithrombotic)

cox2 prevents antithrombotic effects b/c endothelial blood vessel cells

Question 8

coxibs and non-selective NSAIDs hypertension and acute renal failure 2 mechanisms

Answer 8

Decreasing renal blood
flow by inducing leukotriene
production

increase na+ retention, increase blood pressure

Question 9

Aspirin (acetylsalicylic acid), Indomethacin, Sulindac

Answer 9

acetic acid nsaids

Question 10

Ibuprofen, Naproxen

Answer 10

propionic acid nsaids

antiinflammatory

Question 11

Piroxicam

Answer 11

Oxicam nsaid

Question 12

nsaids pain and fever

Answer 12

inhibit due to effects of PGs on nociceptors and
hypothalamus

Question 13

Potential Side Effects of NSAIDs

Answer 13

A- GI upset

B- Aspirin/ NSAIDs-induced asthma

C- Reyes syndrome

D- high BP/ renal failure/ stroke

E- bleeding

Question 14

Acetaminophen

Answer 14

Derived from coal tar

NOT an anti-inflammatory drug

hepatotoxic