final: biologics

Question 1

CDRs

Answer 1

variable domains of antigen recepor on an antibody

12 per antibody molecule

Question 2

phage display technologies

Answer 2

one way to produce monoclonal antibodies

isolate animal phage that binds the target

recovered antibodies amplified with e coli

antibody fragments used as therepeutic agents or converted into intact human immunoglobins with plasmids

Question 3

Immunization of a humanized transgenic mouse.

Answer 3

one way to produce monoclonal antibodies

mouse produces humanized antibodies

Question 4

nivolumab, pembrolizumab, atezolizumab, avelumab

Answer 4

Anti-PD-1 Biologics

anti-cancer immuno-modulator

PD-L1 is expressed by cancer cells to block destruction by t cells

pd1 inhibitors keep t cells active and allow them to kill cancer cells

Question 5

CAR-T therapy

Answer 5

Engineered T-cell receptor specific to cancer cells

Question 6

GLP 1 and protien type

Answer 6

gpcr for diabetes 2