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Cytologie > Microtubuli > Flashcards

Microtubuli Flashcards

1
Q

Cytoskelet

A

Microtubuli
Microfilamenten
Intermediaire filamenten

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2
Q

Wat zijn microtubuli

A

Rigide, holle staafjes

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3
Q

Grootte microtubuli

A

Ongeveer 25 nanometer in diameter

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4
Q

Opbouw

A

Tubuline-eenheden

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5
Q

Tubuline-eenheden

A

A-tubuline
B-tubuline
G-tubuline (centrosoom)

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6
Q

G-tubuline

A

Speelt rol bij initiatie van assemblage van nieuwe microtubuli

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7
Q

Cycli opbouw en afbraak

A

GTP op b-tubuline
Hydrolyse tot GDP
Bindingsaffiniteit wordt minder
Tredmoleneffect

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8
Q

Colchicine en colcemid

A

Behandeling van kanker
Binden op tubuline
Verhinderen polymerisatie

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9
Q

Vincristine en vinblastine

A

Behandeling van kanker

Inhiberen snel delende cellen

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10
Q

Taxol

A

Stabiliseert de microtubuli

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11
Q

MAPs

A

Microtubuli Geassocieerde Proteïnen

Verbinden microtubuli met elkaar of met andere structuren

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12
Q

Dyneines

A

Familie van eiwitten

Transport langs microtubuli richting - einde

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13
Q

Kinesines

A

Familie van eiwitten

Transport langs microtubuli richting + einde

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14
Q

MTOC

A

Microtubulusorganiserende Centra

Centra die de eigenschap hebben om polymerisatie van tubuli te katalyseren

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15
Q

Positief uiteinde

A

Groei

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16
Q

Negatief uiteinde

A

Depolymerisatie

17
Q

Functie

A

Transport van vesikels en organellen
Verplaatsing van chromosomen tijdens mitose
Bouwstenen van centriolen, ciliën en flagellen

18
Q

Centriolen

A

Korte structuren in cytocentrum
0,2 bij 0,4 micrometer
Gefuseerde microtubuli
Plaats waar tubuli aanhechten

19
Q

Aanwezigheid centriolen

A

Niet-delende cellen: 1 paar

Vóór mitose: 2 paren

20
Q

Ciliën

A

Trilharen

21
Q

Flagellen

A

Zweepharen

Cytologie (17 decks)

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