Micro UA part 2 Flashcards

1
Q

Casts
where are they formed?
shape?

A

formed only in the kidney nephron
loop of henely
distal tube
collecting duct

Shape represents tubule

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2
Q

Structure of casts

A

parallel sides
rounded edges
some fragmented

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3
Q

Composition of casts

A

tamm-horsfall (uromodulin)
glycoprotein excreted by RTE - lubrication

constant rate
makes up mucus
‘gels’
not detected by rgnt strip

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4
Q

Formation of casts

A

tam-horsfall RTE protein
fibrils from network loose
futher matrix
urine comp attaches to matrix
cast detaches from RTE

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5
Q

What is casts in urine called

A

cylinduria

occurs more readily if urine flow decreased
pH is acidic
increased electrolytes

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6
Q

T/F forms of casts dont block the urine in the nephron

A

false

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7
Q

patho vs non patho casts

A

patho: renal issue

non patho: dehydration

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8
Q

Types of casts

A

elements/size/shape/time

hyaline - most common

Cellular - Rbc/wbc/rte

fatty

granular

broad - collecting duct
waxy - severe renal stasis

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9
Q

Hyaline cast

A

most frequent
in loop of henely/distal/collecting

0-2 norm
low power

Noth path: excersise/dehydration/heat

Patho: acute glomer, pylnoneph, renal

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10
Q

What do hyaline casts look like when they come from the henely loop?

A

wiggly tails

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11
Q

Hyaline cast morphology

A

hard to see

sternheimer-malbin/phase contrast

parallel with round edges
few granules
cells will stick

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12
Q

RBC casts

A

rbc embedded in matrix
not stuck on outside
free floating rbcs seen
“pos” on blood strip

Non path: rare - extreme exersice

Path: bleeding in nephron assoc w glomerulon

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13
Q

If hgburia is present, what color is the rbc cast?

methgb?

A

orange/red color

methgb is brown/red

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14
Q

What are hgb type casts associated with?

A

associated with aute tubular necrosis
very large amounts toxic to kidneys and result in renal failure

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15
Q

WBC casts

A

wbc embedded in matrix
neutrophils
granular appearance, dont confuse w wbc clumps

Path: infections/inflamm

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16
Q

Pylonephritis

17
Q

Cystitis

A

lower uti doesnt produce wbc casts

18
Q

Bacteria casts

A

bacteria in cast
associated with pylonephritis

wbc and free floating bacteria present

confused w granular casts

RARE

confirm with gram stain

19
Q

RTE casts

A

very serious very rare
tubular destruction

diff from wbc casts use STAINING mononuclear structure

20
Q

Oval fat body casts

A

comp. of fat drop of oval fat body
refractile
confirm with polarized light and fat stain
Sudan III or Oil Red O

Cholesterols - maltese cross

21
Q

mixed cell

A

diff cell types

rbc/wbc: glomerul

wbc/RTE: plyonephritis

22
Q

Granular casts

A

pick up material from urine - degrade “granularity”
crystalize
rbc
wbc
CELLULAR MATERIAL FROM RTE MOST COMMON

23
Q

Granular casts start as

A

start as course and go to fine
must have urinary stasis occur for granular casts to form

24
Q

Waxy cast

A

long term urinary stasis
chronic renal failure
seen with other casts
occur from futher breakdown of gran. casts

brittle refract index
fiber
fragmented square endds
notches
dark pink

25
Broad casts
renal failure casts wider 2-6x than typical cast very long term urinary stasis can form from anytype of cast MOST COMMON WAXY/GRANULAR from distal tube due to dilation (wider walls) collecting duct severe renal flow dec