Micro Summary: Diseases Flashcards
Bacteriodes: Bacilus, Prevotella, Porphoryngeus
B. fragilis, P. bivia, P. melaninogenica, P. gingivalis, Abscess, Bacteremia
Histotoxic Clostridia: C. perfringens, C. septicum
Wound (gas, anaerobic cellulitis, simple), organ, septicemia, food poisoining
C. tetani
Tetanus (CNS, spastic paralysis)
C. botulism
Flaccid paralysis, CN dysfunction, double vision, swallowing difficulties, flaccid paralysis, breathing problems, constipation (infants), classical foodborne botulism: contaminated foods, intoxication, infant botulism: most common form of botulism in US, GI tract colonized, infection, adult infant botulism: GI tract colonized, disrupt normal flroa, toxin production, wound botulism: toxin grows in wound, class A select agent: bioterrorism, biowarfare
C. difficile
Hospital-acquired infectious diarrhea
Campylobacter jejuni
Acute gastroenteritis
Haemophilus influenzae
Children: otitis media/sinusitis, epiglottitis, pneumonia, meningitis/bacteremia; Adults: otitis media, sinusitis, LRT
Mycoplasma pneumoniae
Persistent cough + erythema multiforme + anemia, thrombotic purpura
Escherichia coli
UTIs, neonatal/childhood meningitis
Salmonella
Diarrhea (gastroenteritis), enteric fever (typhoid fever)
Shigella
Dysentery, GI Symptoms of shigellosis vary from mild diarrhea (no blood) to dysentery (low volume, bloody stool). Shigellosis is usually considered a disease of the colon; it may also involve the ileum? S. sonnei infections usually mildest; S. dysenteriae and S. flexneri more severe
Klebsiella
Bloodstream infection, nosocomial pneumonia and urinary tract infection
Yersinia pestis
Plague, diarrhea, lymphadenitis, Bubonic: most common, fevers, chills, weakness, headache, painful swollen lymph nodes, Pneumonic: infection of lungs, fever, cough, difficulty breathing, bloody sputum, Septicemic: generalized (bloodstream)
Chlamydia trachomatis
Serovars A-K: trachoma, cervicitis, PID, etc., Serovars L1-L3: lymphogranuloma venereum (LGV), Chlamydophila pneumonia: bronchitis & pneumonia, Chlamydophila psittaci: zoonotic, pneumonia (psittacosis)
Treponema pallidum
Syphilis
Rickettsia rickettsii
“Rocky Mountain Spotted Fever: Rash localized to extremities, Fever, malaise, severe frontal headache, myalgia and vomiting, Abdominal pain, diarrhea, conjunctivitis, mental confusion, meningitis, respiratory difficulties, renal
dysfunction, and/or myocarditis, Lysis of endothelial cells leads to endothelitis”
Borrelia burgdorferi
Lyme Disease: Early: bull’s eye expanding rash, malaise, fatigue, headache, fever, chills, myalgia, Early-Disseminated: cranial neuropathy, meningitis, radiculoneuropathy, iritis, encrotizing retinis, cardiac dysfunction, Late: oligoarthritis, dermatologic syndromes, neurologic demylination
Bacillus anthracis
Cutaneous (95%): exposure of abraded skin to spores, purpitic painless papule, black eschar, enlarged lymph nodes, Inhalational (5%): flu-like, mediastinal widening, hemorrhagic mediastinitis, hemorrhagic meningitis, GI (sporadic): uncooked meat, GI symptoms
Francisella tularensis
Tularemia: Ulceroglandular, Pharyngeal, Pneumonic, Oculoglandular, Typhoidal, Glandular
Helicobacter pylori
Mild GI inflammation (chronic gastritis), Duodenal or gastric ulcers due to inflammation (ammonia/urease, VacA, CagA), Gastric cancer or lymphoma
Enterococcus faecium
Bloodstream infection, endocarditis, UTIs
Staphylococcus aureus
Skin & soft tissue disease (abscess, cellulitis, osteomyelitis, myositis, septic arthritis, impetigo, folliculitis, furuncles, fasciitis), Disseminated disease (toxic shock syndrome (intoxication), septicemia, endocarditis), Device infections (*central venous catheters, implanted devices, post-surgical infections), CA-MRSA (presence of Panton-Valentine Leukocidin (PVL) gene), Superantigens (food poisoning)
Staphylococcus epidermidis
Nosocomial infections w/ IV lines or implanted foreign materials
Acinetobacter baumanii
Ventilator associated pneumonia (VAP)
Neisseria meningitidis
Meningitis
Neisseria gonorrhoeae
M: acute urethritis, urethral dischare, dysuria, most resolve, F: asymptomatic or cervicitis, urethritis, PID (bilateral abdominal pain, tenderness fever), N: conjunctivitis
Streptococcus pyogenes
Bacteremia, pneumonia, bone & joint infections, meningitis, endocarditis, Mucosal infections: streptococcal pharyngitis,Pyogenic infections: necrotizing faciitis (attachment from M protein & LTA), Toxigenic: toxic shock syndrome, scarlet fever, Non-suppurative or immunologic: rheumatic fever (inadvertent autoimmunity molecular mimicry), poststreptococcal glomerulonephritis (hematuria/Coca-cola urine, edema, hypertension)
Streptococcus pneumoniae
Respiratory Disease: upper (otitis media, sinusitis, conjunctivitis) & lower (CA-pneumonia, death), Disseminated: bacteremia, meningitis, bacterial peritonitis, septic arthritis, osteomyelitis
Listeria monocytogenes
Meningitis in babies, bacteremia or meningitis in immunocompromised
Legionella pneumophila
Legionnaires’ disease & Pontiac fever, cough, fever, diarrhea
Pseudomonas aeruginosa
Shock, cystic fibrosis, burn infections, catheters (UTIs), & IV lines
Mycobacterium tuberculosis
Tuberculosis: cough, fever, difficulty breathing
Mycobacterium leprae
Leprosy
Corynebacterium diphtheria
C. diphtheriae cells remain on the mucosal epithelium (not invasive), some are absorbed & enter circulation to damage internal organs, causing death
Vibrio cholera
“fluid/electrolyte loss & diarrhea, severe cholera: diarrheal fluid has a pale yellow/brown color with flecks of small
white mucous material (““rice water stool””), poor skin turgor, sunken eyes, vomiting, dehydration, cardiac problems, shock, coma, & death”
Bordetella pertussis
tracheitis and bronchitis, with accumulation of mucus, cells, and bacteria in the airways; mucociliary elevator is impaired; hemorrhages & vomiting