Micro Final Details Flashcards
Action of the diptheria and pseudomonas exotoxin A
Robosylate and inactivate EF-2 (AB-toxin)
Action of pertussis toxin
Inactivated Gi–> increased cAMP
Impairs phagocytosis
Cleaves snare proteins, inhibiting the release of neurotransmitters
Botlinum (prevent Ach release) and tetnus toxin (prevents GABA relase)
Phospholipase that degrades cell membranes
C. perfringings Alpha Toxin
mechanism of streptolysin O toxin
Lyses RBC
Approximate MHC-II and T-cell receptors resulting in overwhelming release of INF-y and IL-2
S. pyogenes exotoxin A
S. aureus TSST-1
ability to take up naked DNA from the environment and incorporate it into it’s own genome
Transformation
Phage DNA incorportated into bacterial chromosome
Generalized tranduction
Bacterial DNA accidentally incorporated into viral genome when it is excized
Specialized transduction
G (+) Rods
Clostridium (anaerobe) (Cant Breath Air)
Corynebacterium
Listeria
Bacillus (aerobe) (Nagging Pests Must Breath)
Mycobacterium (acid fast)
Binds Fc of IgG preventing complement formation
S. aureus
Protein A
Lancet shaped diplococci with an IgA protease
S. pneumonia
Optochin sensitive
G(+) rods with metachromatic granules
C. diptheriae
Location of GABA inhibition by tetanus toxin
Inhibits SNAREs in the **Renshaw cells **of the GABAercic
neurons of the spinal cord
Drug most commonly responsible for psuedomembranous colitis
Clindamycin and ampicillin
Tumbling G(+) rod
Tx?
Listeria
Ampicillin
Primary TB
Gohn focus (mid zone)
Hilar lymphadenopathy
–>Gohn complex
2’ TB
Fibrocaseous necrotic lesion in upper lobes
Two virulence factors of mycobacterium
Cord Factor: Inhibits macrophage matuation and induces TNF-alpha release
Sulfatide: Surface glycolipid which **inhibits lysosomal fusion **(reason why they can live inside macrophages)
Leprosy infection with poor Th1 response?
Strong Th1 response?
Poor Th1: Lepromatous–> diffuse and communicable
Stong Th1: Tuberculoid: hypoesthtic nodues and hairless plaques
G(-) Rod, Lactose nonfrementer, Oxidase (-)
Shigella
Salmonella
Proteus
Culture difference between salmonella and shigella?
Salmonella–> motile H2S (+)
Shigella–> NON-motile H2S (-)
G(-) Rod lactose fermenters
E. coli
Klebsiella
Culture difference between klebsiella and E.coli
E. coli Indole (+)
Klebsiella Indole (-)
Vaccine for this bug contains capsular polysaccharide (polyribosylribitol phosphate) conjucated to diptheria toxoid
H. influensza
E. coli infection that is fecal leukocyte (+)
EIEC
Bloody diarrhea and sorbitol non-fermenter
EHEC (O157:H7)
rose spots on abdomen, fever and diarrhea
Typhoid fever
Salmonella typhi
Spirochete visualized on giesma of wright stain
Borellia
(Treponema is too small)
Obligate intracellular organism that needs CoA and NAD+
Rickettsia sp.
Centrifugal rash sparing the palms and soles
R. prowazekii–> enpidemic typhus–> human louse
monocytes with berry-like inclusions
Ehlichiosis
Cell wall lacking muramic acid
Chlamydia
Follicular conjuctivits chlamydia types
A, B, C
Causes blindiness in africa
African Blindness Chlamydia
Types of chlmydia that cause PID and Urethritis
types D-K
Sexually transmitted…D-K…Think about it.
Lymphgrnauloma venereum
Painful lyphadenitis and ulceration
Chlamydia L1, L2 and L3
Anemia with pneumonia
M. pneumoniae
Cold agglutinins–> IgM binds to RBC in periphery–> lysed in spleen
Anemia resolves wheni infection is Tx’ed
