Micro Final Details Flashcards

1
Q

Action of the diptheria and pseudomonas exotoxin A

A

Robosylate and inactivate EF-2 (AB-toxin)

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2
Q

Action of pertussis toxin

A

Inactivated Gi–> increased cAMP

Impairs phagocytosis

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3
Q

Cleaves snare proteins, inhibiting the release of neurotransmitters

A

Botlinum (prevent Ach release) and tetnus toxin (prevents GABA relase)

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4
Q

Phospholipase that degrades cell membranes

A

C. perfringings Alpha Toxin

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5
Q

mechanism of streptolysin O toxin

A

Lyses RBC

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6
Q

Approximate MHC-II and T-cell receptors resulting in overwhelming release of INF-y and IL-2

A

S. pyogenes exotoxin A

S. aureus TSST-1

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7
Q

ability to take up naked DNA from the environment and incorporate it into it’s own genome

A

Transformation

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8
Q

Phage DNA incorportated into bacterial chromosome

A

Generalized tranduction

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9
Q

Bacterial DNA accidentally incorporated into viral genome when it is excized

A

Specialized transduction

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10
Q

G (+) Rods

A

Clostridium (anaerobe) (Cant Breath Air)

Corynebacterium

Listeria

Bacillus (aerobe) (Nagging Pests Must Breath)

Mycobacterium (acid fast)

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11
Q

Binds Fc of IgG preventing complement formation

A

S. aureus

Protein A

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12
Q

Lancet shaped diplococci with an IgA protease

A

S. pneumonia

Optochin sensitive

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13
Q

G(+) rods with metachromatic granules

A

C. diptheriae

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14
Q

Location of GABA inhibition by tetanus toxin

A

Inhibits SNAREs in the **Renshaw cells **of the GABAercic

neurons of the spinal cord

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15
Q

Drug most commonly responsible for psuedomembranous colitis

A

Clindamycin and ampicillin

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16
Q

Tumbling G(+) rod

Tx?

A

Listeria

Ampicillin

17
Q

Primary TB

A

Gohn focus (mid zone)

Hilar lymphadenopathy

–>Gohn complex

18
Q

2’ TB

A

Fibrocaseous necrotic lesion in upper lobes

19
Q

Two virulence factors of mycobacterium

A

Cord Factor: Inhibits macrophage matuation and induces TNF-alpha release

Sulfatide: Surface glycolipid which **inhibits lysosomal fusion **(reason why they can live inside macrophages)

20
Q

Leprosy infection with poor Th1 response?

Strong Th1 response?

A

Poor Th1: Lepromatous–> diffuse and communicable

Stong Th1: Tuberculoid: hypoesthtic nodues and hairless plaques

21
Q

G(-) Rod, Lactose nonfrementer, Oxidase (-)

A

Shigella

Salmonella

Proteus

22
Q

Culture difference between salmonella and shigella?

A

Salmonella–> motile H2S (+)

Shigella–> NON-motile H2S (-)

23
Q

G(-) Rod lactose fermenters

A

E. coli

Klebsiella

24
Q

Culture difference between klebsiella and E.coli

A

E. coli Indole (+)

Klebsiella Indole (-)

25
Q

Vaccine for this bug contains capsular polysaccharide (polyribosylribitol phosphate) conjucated to diptheria toxoid

A

H. influensza

26
Q

E. coli infection that is fecal leukocyte (+)

A

EIEC

27
Q

Bloody diarrhea and sorbitol non-fermenter

A

EHEC (O157:H7)

28
Q

rose spots on abdomen, fever and diarrhea

A

Typhoid fever

Salmonella typhi

29
Q

Spirochete visualized on giesma of wright stain

A

Borellia

(Treponema is too small)

30
Q

Obligate intracellular organism that needs CoA and NAD+

A

Rickettsia sp.

31
Q

Centrifugal rash sparing the palms and soles

A

R. prowazekii–> enpidemic typhus–> human louse

32
Q

monocytes with berry-like inclusions

A

Ehlichiosis

33
Q

Cell wall lacking muramic acid

A

Chlamydia

34
Q

Follicular conjuctivits chlamydia types

A

A, B, C

Causes blindiness in africa

African Blindness Chlamydia

35
Q

Types of chlmydia that cause PID and Urethritis

A

types D-K

Sexually transmitted…D-K…Think about it.

36
Q

Lymphgrnauloma venereum

A

Painful lyphadenitis and ulceration

Chlamydia L1, L2 and L3

37
Q

Anemia with pneumonia

A

M. pneumoniae

Cold agglutinins–> IgM binds to RBC in periphery–> lysed in spleen

Anemia resolves wheni infection is Tx’ed