Immunosupressants

Question 1

Block the differentiation of T-cells by inhibiting cacineurin–> thus preventing the production of IL-2 and its receptor

Answer 1

Cyclosporin

Question 2

Carries a major side effect of nephrotoxicity

Answer 2

Cyclosporin

Question 3

MOA of tacrolimus (FK-506)

Answer 3

Binds to FK-binding protein–> inhibiting calcineurin and secretion of IL-2

Question 4

Sirolimus also known as

Answer 4

rapamycin

Question 5

Inhibits T-cell proliferation in response to IL-2

Answer 5

sirolimus

Question 6

MOA of azathioprine

Answer 6

antimetabolite precursor of 6-MP–> toxic to proliferating lymphocytes

Question 7

Be careful giving this drug with Azathioprine

Answer 7

Allopurinol

Question 8

OKT3 also known as

Answer 8

Muromonab-CD3

Question 9

Muromonab-CD3 MOA

Answer 9

Monoclonal Ab that binds to CD3 (common to all T-cells) and therefore block activation of T-cells

Question 10

Inhibits IMP-dehydrogenase (inositol monophosphate)–> Prevents guanine synthisis

Answer 10

Mycohpneolate

Question 11

What is the major adverse effect of mycophenolate

Answer 11

Carries increased risk for lymphoma

Question 12

CD25 blocker

Answer 12

Daclizumab