Micocirculation Flashcards
Average velocity of blood through capillaries is depedent upon
Arteriole constriction
Venule pressure
Endothelial and local factors
Salutes move across the capillary wall via
Diffusion, filtration, and pinocytosis
Average velocity though capillaries is
1 mm/s
Fick principle
Trans capillary effluent rate (mass/time) = flow (Q) [(arterial concentration [X]) - (venous concentration)]
Factors (Starling Forces) driving fluid filtration
Hydrostatic or blood pressure within the capillary
Interstitial protein oncotic pressure
Factors driving fluid pressure
Interstitial fluid pressure
Plasma protein oncotic pressure
Effect of increases arteriolar resistance on capillary pressures
Increases resistance to inflow Decreased capillary flow decreases capillary hydrostatic pressure Increases reabsorption Decreased mean capillary pressure
Effect of increases venous pressure/increased venous resistance
Decreased pressure gradient (P1-P2); increases resistance to outflow
Increased capillary hydrostatic pressure
Increased filtration
Extreme example – edema formation cardiac failure
Increased mean capillary pressure
Lymph system
In direct contact with interstitial space allowing free flow of large molecules
Valves allow for unidirectional flow
Maintains low. Interstitial hydrostatic an oncotic pressures
Dehydration effect on capillary filtration/reabsorption
Decreased mean capillary pressure