Longterm Regulation

Question 1

Sympathetic or parasympathetic stimulation get increases renin release

Answer 1

Sympathetic

Question 2

Injection of what into the renal artery triggers renin release

Answer 2

Norepinephrine

Question 3

Mechanisms for renin release

Answer 3

Renal bars-receptors sense a change in glomerular arterial pressure
- decreased pressure/stretch on the juxtagomerular cells triggers renin release
Decreases in salt concentration in adjacent tubule cells (macula densa) triggers renin release

Question 4

Increased stimulation of RAAS results in

Answer 4

Increased TPR via angiotensin IIs direct vasoconstrictive actions on vasculature
Increased Na+ retention
Increased water retention
Increased total volume retention

Question 5

ADH acts on what to increase water reabsorption

Answer 5

Renal collecting ducts

Question 6

ANP

Answer 6

A peptide released by the atrial cells during excessive stretch
Primary trigger for release is hypervolemia
Main actions are on the kidney to increase dieresis and natriuresis
Actions on vasculature are independent of endothelium

Question 7

ANP direct renal action

Answer 7

Inhibits aldosterone production and collecting duct Na+ reabsorption

Question 8

Hypertension/heart failure

Answer 8

Actions of ANP may be masked by high levels of angiotensin II