MHC Molecules / HLA genes

Question 1

What are MHC molecules?

Answer 1

Specialized proteins located in membrane of APCs

Question 2

Function of MHC molecules?

Answer 2

Display of PEPTIDE ANTIGENS for RECOGNITION by T-CELLS

Question 3

Class I MHC is expressed on

Answer 3

All nucleated cells

Question 4

Class I MHC presents ___________ proteins to _____________

Answer 4

Cytosolic / CD8+ T cells

Question 5

Class II MHC presents ___________ proteins to _____________

Answer 5

Extracellular / CD4+ T Cells

Question 6

What are HLA genes

Answer 6

Genes which code for the molecules (MHC I and II)

Question 7

HLA function in organ transplantation

Answer 7

Determine wheter a patient will REJECT or ACCEPT a donor’s organ

Question 8

MHC I is coded by 3 gene loci, which are those?

Answer 8

HLA-A
HLA-B
HLA-C

Question 9

Sibilings have a ______ chance of having the same HLA

Answer 9

1/4

Question 10

MHC II molecules are coded by 5 gene loci, which are those?

Answer 10

HLA-DP
HLA-DQ
HLA-DM
HLA-DR
HLA-DO

Question 11

Which MHC molecules are associated with predisposition for autoinmune diseases?

Answer 11

MHC II