CYTOKINES

Question 1

Which cells produce IL-1?

Answer 1

Macrophages
Dendritic cells (APCs)

Question 2

Secretion of IL-1 induces

Answer 2

Fever
Inflammation
Chemotaxis

Question 3

Which cells produce IL-2?

Answer 3

T-Cells upon activation

Question 4

Secretion of IL-2 induces

Answer 4

Growth of CD8+/CD4+/NK Cells

Question 5

Which cells produce IL-4?

Answer 5

Th-2 Cells

Question 6

Secretion of IL-4 induces

Answer 6

Growth of Th-2 and B Cells
Class-switching from IgM to IgE

Question 7

Which cells produce IL-5?

Answer 7

Th-2 Cells

Question 8

Secretion of IL-5 induces

Answer 8

Growth of B cells and eosinophils.
Class-switching from IgM to IgA

Question 9

Which cells produce IL-6?

Answer 9

Macrophages

Question 10

Secretion of IL-6 induces

Answer 10

Chemotaxis of neutrophils

Question 11

Which cells produce IL-10?

Answer 11

Macrophages, T-Helper cells and T-reg cells

Question 12

Secretion of IL-10 induces

Answer 12

Decrease in expression of MHC II molecules
Decrease in production of inflammatiry cytokines

Question 13

Which cells produce IL-12?

Answer 13

Macrophages
Dendritic cells

Question 14

Secretion of IL-12 induces

Answer 14

Stimulation of growth of Th-1 Cells and NK Cells
(ANTIVIRAL EFFECT)

Question 15

Which cells produce IFN-Gamma?

Answer 15

T Cells
NK Cells

Question 16

Secretion of IFN-Gamma induces

Answer 16

Stimulation of macrophages to kill phagocytised pathogens
Stimulation of NK cells to kill viruses
(ANTIVIRAL)

Question 17

Which cells produce TNF-Alfa

Answer 17

Macrophages

Question 18

Secretion of TNF-Alfa induces

Answer 18

Stimulation of the endothelium for WBC RECRUITMENT