Hipersensitivity Reactions

Question 1

Anaphylactic type reaction is characteristic of

Answer 1

Type I HS

Question 2

Type I HS has 2 phases:

Answer 2

Inmediate (minutes)
Late (12-24 hours)

Question 3

Type I HS is mainly mediated by

Answer 3

Formation of IgE Antibodies

Question 4

Type I HS clinical features

Answer 4

Edema + Urticaria + Broncoconstriction + Rhinitis

Question 5

In the first exposure: Once APCs present antigen to T-Helper cells, what is the next step in Type I HS

Answer 5

1) Activation of Th2 Cells = Increase of IL-4
2) Increased IL-4 = B-Cell class switching to IgE

Question 6

IgE binds to Fc-epsilon receptor on

Answer 6

Mast cells and Basophils

Question 7

2nd exposure in Type I HS

Answer 7

IgE antibodies crosslink = DEGRANULATION of Basophils and Mast cells

Question 8

Examples of Type I HS

Answer 8

ASTHMA
RHINITIS
HIVES

Question 9

Type II HS is mediated by

Answer 9

ANTIBODIES

Question 10

Type II is characterized by presence of _____________ against _____________

Answer 10

IgG Antibodies / Cell surface Antigen

Question 11

Antibodies lead to cellular damage via 3 mechanism

Answer 11

1) COMPLEMENT ACTIVATION
2) OPSONIZATION
3) ABNORMAL CELLULAR RESPONSES

Question 12

The mechanism of abnormal cellular response in Type II HS is feature of

Answer 12

Myasthenia Gravis

Question 13

Examples of Type II HS

Answer 13

Autoinmune Hemolytic Anemia
Graves Diseases
Rheumatic fever
Myasthenia Gravis
GoodPasteur Syndrome

Question 14

Type III HS is mediated by

Answer 14

INMUNE COMPLEX

Question 15

Mechanism of Type III HS

Answer 15

Deposition of Inmune Complexes (Antigen-Antibody) in tissues that leads to complement activation

Question 16

Vasculitides are an example of

Answer 16

Type III HS

Question 17

Examples of Type III HS

Answer 17

LES
PS Glomerulonephritis
Serum sickness (Passive Immunity)
Arthus Reaction (DT vaccine)

Question 18

Type IV HS is mediated by

Answer 18

T-Cell-Mediated / Also known as Delayed Type

Question 19

Abnormal activation of T-Cells is feature of

Answer 19

Type IV HS

Question 20

CD4+ acts via ________ and produce ___________

Answer 20

MHC II / Harmful Cytokines

Question 21

CD8+ acts via _________ and produce ___________

Answer 21

MHC I/ Direct Cytotoxicity

Question 22

Examples of Type IV HS

Answer 22

Contact Dermatitis
Graft vs Host disease
Dm Type I
Tuberculin reaction

Question 23

LES is an example of

Answer 23

Type III HS

Question 24

DM Type I is an example of

Answer 24

Type IV HS

Question 25

Rheumatic Feveres is an example of

Answer 25

Type II HS

Question 26

Graft vs Host disease is an example of

Answer 26

Type IV HS

Question 27

Poststreptococcal Glomerulonephritis is an example of

Answer 27

Type III HS

Question 28

Autoinmune Hemolytic Anemia is an example of

Answer 28

Type II HS

Question 29

Graves Disease / Myasthenia Gravis are examples of

Answer 29

Type II HS

Question 30

Goodpasteur Syndrome is an example of

Answer 30

Type II HS