MHC in Antigen Presentation Flashcards
What does the TCR recognize when interacting with an APC?
MHC
Polymorphic region
Peptide
All MHC I molecules are formed with these 2 structures
Alpha and beta2 microglobulin
This is essential for expression of all HLA class I molecules and is coded by a non MHC gene
Beta2 microglobulin
Where are the polymorphic binding residues found on an MHC I molecule?
Alpha 1 and alpha 2 domains
These make up the peptide binding groove on the MHC I molecule
Alpha 1 and alpha 2 domains
In what domain is diversity found in the MHC class I molecules?
Alpha domain
All MHC II molecules are formed with these 2 structures
Alpha and beta chain
Which structure of HLA-DR is nonpolymorphic?
Alpha chain
Which structure of the HLA-DR is highly polymorphic?
Beta chain - a lot of alleles
The alpha and beta chains of these MHC II molecules are polymorphic
HLA-DP and HLA-DQ
What type of allele dominance do MHC gene show?
Co-dominant; phenotype from both parents will be expressed
Think of how in blood type if parents are A and B, child will be AB
Expression of this MHC class can be induced by certain cytokines
MHC class II
These 3 cells are considered professional APCs
Dendritic cells
Macrophages
B cells
Only this group of cells makes MHC class II receptors
APCs
These residues in the MHC I have less variability and hold the peptide in place
Anchor residues