MHC in Antigen Presentation Flashcards

1
Q

What does the TCR recognize when interacting with an APC?

A

MHC
Polymorphic region
Peptide

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2
Q

All MHC I molecules are formed with these 2 structures

A

Alpha and beta2 microglobulin

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3
Q

This is essential for expression of all HLA class I molecules and is coded by a non MHC gene

A

Beta2 microglobulin

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4
Q

Where are the polymorphic binding residues found on an MHC I molecule?

A

Alpha 1 and alpha 2 domains

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5
Q

These make up the peptide binding groove on the MHC I molecule

A

Alpha 1 and alpha 2 domains

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6
Q

In what domain is diversity found in the MHC class I molecules?

A

Alpha domain

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7
Q

All MHC II molecules are formed with these 2 structures

A

Alpha and beta chain

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8
Q

Which structure of HLA-DR is nonpolymorphic?

A

Alpha chain

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9
Q

Which structure of the HLA-DR is highly polymorphic?

A

Beta chain - a lot of alleles

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10
Q

The alpha and beta chains of these MHC II molecules are polymorphic

A

HLA-DP and HLA-DQ

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11
Q

What type of allele dominance do MHC gene show?

A

Co-dominant; phenotype from both parents will be expressed
Think of how in blood type if parents are A and B, child will be AB

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12
Q

Expression of this MHC class can be induced by certain cytokines

A

MHC class II

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13
Q

These 3 cells are considered professional APCs

A

Dendritic cells
Macrophages
B cells

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14
Q

Only this group of cells makes MHC class II receptors

A

APCs

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15
Q

These residues in the MHC I have less variability and hold the peptide in place

A

Anchor residues

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16
Q

This influences peptide binding in the alpha 1 and alpha 2 domains of MHC I

A

Allelic variation

17
Q

What is the clinical relevance of allele specific binding?

A

Allelic variation —> better or worse ability to bind with antigens
Can also contribute to better self-binding —> autoimmunity

18
Q

Which MHC class is able to bind bigger peptides?

A

Class II

19
Q

This MHC class is responsible for presenting exogenous antigens

A

Class II

20
Q

What MHC class is responsible for presenting endogenous antigens?

A

Class I

21
Q

What cell is able to transfer an exogenous antigen to MHC I?

A

Dendritic cells - this is called cross presentation
Allows them to activate cytotoxic cells

22
Q

What is a risk associated with limited polymorphism in MHC genes?

A

Increased susceptibility to certain illnesses or not creating a desired response to a vaccine