Methylxanthines, Anti-IgE, Anti-IL5, Anti-IL4/IL13, and Phosphodiasterase-4 inhibitor medications

Question 1

What is the Methylxanthine drug?

Answer 1

Brand: Theochron
Generic: Theophylline

Question 2

Theophylline (Brand: Theochron) dosage form and age for dosing

Answer 2

ER 12 hour tablets, ER 24 hour tablets, ER 24 hour Capsules, liquid
-adult dosing only for acute exacerbation, chronic management

Question 3

Theophylline (Brand: Theochron) side effects and counseling tips

Answer 3

SE: insomnia, gastrointestinal upset, hyperactivity, hypotension, tremor
Dose related toxicity: tachycardia, nausea, vomiting, headache, seizures, arrythmiaas
CI: peptic ulcer disease, arrythmias, seizure disorders
DI: increases concentration (cimetidine, erythromycin, clarithromycin, ciprofloxacin, ticlopidine)
decreases concentration (phenobarbital, phenytoin, carbamazepine, rifampin, smoking)

Question 4

What is the Anti-IgE medication?

Answer 4

Brand: Xolair
Generic: Omalizumab

Question 5

Omalizumab (Brand: Xolair) dosing form and dosing age

Answer 5

Dosage form: prefilled syringe
-dosing age approved for 6+ years

Question 6

Omalizumab (Brand: Xolair) side effects and counseling tips

Answer 6

SE: headache, injection site reactions, arthralgias, thrombocytopenia, pharyngitis, sinusitis, upper respiratory tract infections
BOXED WARNING: anaphylaxis
-do not give more than 150 mg per injection site
-approved for moderate to severe persistent asthma with symptoms inadequately controlled with ICS

Question 7

What are the Anti-IL5 medications?

Answer 7

Brand: Nucala; Generic: Mepolizumab
Brand: Cinqair; Generic: Reslizumab
Brand: Fasenra; Generic: Benralizumab

Question 8

What are the Anti-IL5 dosing age and form?

Answer 8

6+ for Mepolizumab (Brand: Nucala)
18+ for Reslizumab (Brand: Cinqair)
adults only for Benralizumab (Brand: Fasenra)
-dosage form: Injection only

Question 9

What are Mepolizumab (Brand: Nucala) side effects and counseling tips?

Answer 9

SE: headache, injection site reaction, arthralgias, Herpes Zoster infection
Precaution: Anaphylaxis
-indicated as an add-on fr matienence treatment of severe asthma with an eosinophilic phenotype

Question 10

What are the Reslizumab (Brand: Cinqair) side effects and counseling tips?

Answer 10

SE: injection site reactions, myalgias, increased creatinine phosphokinase
BOXED WARNING: anaphylaxis
-indicated as an add-on for matienence treatment of severe asthma with an eosinophilic phenotype

Question 11

What are the Benralizumab (Brand: Fasenra) side effects and counseling tips?

Answer 11

SE: injection site reactions, antibody development, headache, pharyngitis, fever
Precaution: anaphylaxis
-indicated as an add-on matienence for severe asthma with an eosinophilic phenotype

Question 12

What are the Anti-IL4/IL 13 drugs?

Answer 12

Brand: Dupixent; Generic: Dupilumab

Question 13

What are the side effect, dosage form and age for Dupilumab (Brand: Dupixent)?

Answer 13

Dosage form: injection
Dosing age: 12+
SE: injection site reactions, antibody development, arthralgias, conjunctivitis
Precaution: Anaphylaxis
-Indicated as add-on medication for patients with moderate-to-severe asthma with eosinophilic phenotype or oral corticosteroid dependent asthma

Question 14

What are the phosphodiaesterase-4 inhibitor drugs?

Answer 14

Brand: Daliresp Generic: Roflumilast

Question 15

What is the indication, Side effects, and dosage form for Roflumilast (Brand: Daliresp)?

Answer 15

COPD only; adult dosing age
tablets
SE: headache, weight loss, diarrhea, nausea
-liver function test, weight to monitor